23282-97-5

Upstream product

• 86738-35-4 2-(methylsulfonyl)-5-phenyl-1,3,4-thiadiazole 
• 100-46-9 benzylamine 
• 19948-90-4 N-(5-phenyl-1,3,4-thiadiazol-2-yl)benzamide 
• 7701-07-7 benzaldehyde 4-benzyl-thiosemicarbazone 
• 120811-69-0 2-benzoyl-N-benzylhydrazinecarbothioamide 
• 622-78-6 Benzyl isothiocyanate 
• 613-94-5 benzoic acid hydrazide 
• 1950-20-5 benzyl-dithiocarbamic acid ethyl ester 
• 98-88-4 benzoyl chloride 
• 2002-03-1 2-amino-5-phenyl-1,3,4-thiadiazole 

Downstream Products

• 63586-60-7 N-benzyl-N-(5-phenyl-[1,3,4]thiadiazol-2-yl)-acetamide 
• 63604-39-7 2-benzylimino-5-phenyl-3-(toluene-4-sulfonyl)-2,3-dihydro-[1,3,4]thiadiazole 
• 63586-58-3 N-benzyl-N-(5-phenyl-[1,3,4]thiadiazol-2-yl)-toluene-4-sulfonamide 

Relevant academic research and scientific papers

Design and Synthesis of 1,3,4-Thiadiazole Derivatives as Novel Anticancer and Antitubercular Agents

A series of novel 5-phenyl-substituted 1,3,4-thiadiazole-2-amines were designed, synthesized, and screened for their antitumor and antitubercular activities. The target compounds were synthesized starting from isocyanates and acid hydrazides by convention

Synthesis of 2-amino-substituted-1,3,4-thiadiazoles via 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) mediated intramolecular C-S bond formation in thiosemicarbazones

An effective oxidative intramolecular cyclization (C-S bond formation) of thiosemicarbazones using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) has been developed to afford a diverse array of 2-amino-substituted-1,3,4-thiadiazoles. The attractive featu

Regioselective synthesis of 2-amino-substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives via reagent-based cyclization of thiosemicarbazide intermediate

A regioselective, reagent-based method for the cyclization reaction of 2-amino-1,3,4-oxadiazole and 2-amino-1,3,4-thiadiazole core skeletons is described. The thiosemicarbazide intermediate 3 was reacted with EDC·HCl in DMSO or p-TsCl, triethylamine in N-

Dithiocarbamate as an efficient intermediate for the synthesis of 2-amino-1,3,4-thiadiazoles in water

A new and facile protocol for the synthesis of 2-amino-1,3,4-thiadiazoles in water is described. Reaction of acid hydrazides with easily prepared dithiocarbamates gives the corresponding thiadiazoles in moderate to excellent yields. 2-Amino-1,3,4-oxadiazoles were not observed as side products using this procedure.

New access to pyrazole, oxa(thia)diazole and oxadiazine derivatives

1,4-Disubstituted thiosemicarbazides 1b-f reacted with ethenetetracarbonitrile (5) in dimethylformamide with formation of 2-substituted 5-phenyl-1,3,4-thiadiazoles 2a-f and 2-substituted 5-phenyl-1,3,4-oxadiazoles 4a-f. Upon addition of 5 to 1c-e in chlorobenzene, 3-amino-2-benzoyl-4,5,5- tricyano-2,5-dihydro-1H-pyrazole- 1-[N-(4-tricyanovinyl)phenyl]carbothioamide (12), 5-benzylamino-, and 5-allylamino-4-benzoyl-2,3-dihydro-[1,3,4]thiadiazol- 2,2-dicarbonitrile (13a,b) and 5-amino-1-benzoylpyrazole-3,4-dicarbonitrile (14) as well as 2-phenyl-4H-[1,3,4]-oxadiazine-5,6-dicarbonitrile (15) were formed. Rationales for the role of the solvent and the conversions observed are presented.