19948-90-4

Upstream product

• 2002-03-1 2-amino-5-phenyl-1,3,4-thiadiazole 
• 98-88-4 benzoyl chloride 
• 58975-55-6 N-(2-benzoylhydrazine-1-carbonothioyl)benzamide 
• 532-55-8 Benzoyl isothiocyanate 
• 96133-99-2 C₁₀H₁₃N₃OS 
• 78968-35-1 1-Isopropylideneamino-2-thiobenzamidoguanidine 
• 78968-45-3 1-benzylideneamino-2-thiobenzamidoguanidine 
• 5351-66-6 benzoyl thiosemicarbazide 
• 942-91-6 Carboxymethyl dithiobenzoate 
• 5333-86-8 ethyl benzimidate hydrochloride 
• 65-85-0 benzoic acid 

Downstream Products

• 104830-86-6 N-(5-phenyl-1,3,4-thiadiazol-2-yl)phenylimidoyl chloride 
• 104830-99-1 1-(5-phenyl-1,3,4-thiadiazol-2-yl)-5-phenyltetrazole 
• 2002-03-1 2-amino-5-phenyl-1,3,4-thiadiazole 
• 23282-97-5 N-benzyl-5-phenyl-1,3,4-thiadiazole-2-amine 

Relevant academic research and scientific papers

Novel fluorescent N,O-chelated fluorine-boron benzamide complexes containing thiadiazoles: Synthesis and fluorescence characteristics

A series of N-(5-phenyl-1,3,4-thiadiazol-2-yl)benzamide derivatives and their corresponding BF2 complexes were synthesized, and their photophysical properties were determined. The effect of the derivatives with various substituents on the benza

Synthesis, biological evaluation, and molecular docking studies of 1,3,4-thiadiazol-2-amide derivatives as novel anticancer agents

A series of 1,3,4-thiadiazol-2-amide derivatives (5a-5y) have been designed and synthesized, and their biological activities were also evaluated as potential antiproliferation and FAK inhibitors. Among all the compounds, 5h showed the most potent activity

New access to pyrazole, oxa(thia)diazole and oxadiazine derivatives

1,4-Disubstituted thiosemicarbazides 1b-f reacted with ethenetetracarbonitrile (5) in dimethylformamide with formation of 2-substituted 5-phenyl-1,3,4-thiadiazoles 2a-f and 2-substituted 5-phenyl-1,3,4-oxadiazoles 4a-f. Upon addition of 5 to 1c-e in chlorobenzene, 3-amino-2-benzoyl-4,5,5- tricyano-2,5-dihydro-1H-pyrazole- 1-[N-(4-tricyanovinyl)phenyl]carbothioamide (12), 5-benzylamino-, and 5-allylamino-4-benzoyl-2,3-dihydro-[1,3,4]thiadiazol- 2,2-dicarbonitrile (13a,b) and 5-amino-1-benzoylpyrazole-3,4-dicarbonitrile (14) as well as 2-phenyl-4H-[1,3,4]-oxadiazine-5,6-dicarbonitrile (15) were formed. Rationales for the role of the solvent and the conversions observed are presented.

Synthesis of some nitrogen heterocycles under microwave irradiation in solventless system

A Superior and fast method of synthesis of some nitrogen heterocycles under microwave irradiation in solventless system is described.

Synthesis of 6-Aroylimino-2-aryl-1,3,4-thiadiazolothiadiazolines

Reaction of 2-amino-5-aryl-1,3,4-thiadiazoles (V) with aroyl isothiocyanates gives 2-aroylamino-5-aryl-1,3,4-thiadiazoles (VII) and N-aroyl-N'-(5-aryl-1,3,4-thiadiazol-2-yl)thioureas (VIII).Contrary to earlier reports, cyclisation of VIII in the presence of PCl5 in POCl3 yields 6-aroylimino-2-aryl-1,3,4-thiadiazolo-thiadiazolines (X).Cyclisation of VIII in the presence of other oxidising agents also leads to X.

Synthesis of s-Triazolo-thiadiazoles

1-(5-Aryl-1,3,4-thiadiazol-2-yl)-5-aryltetrazoles (VI) have been obtained by the reaction of 2-aroylamino-5-aryl-1,3,4-thiadiazoles (IV) with phosphorus pentachloride and azidolysis of the resulting imidoyl chlorides.The products obtained on thermolysis o

Derives de la dihydro-2,4 triazole-1,2,4 thione-3 et de l'amino-2 thiadiazole-1,3,4 a partir de nouvelles thiosemicarbazones d'esters

A new general synthesis of 4,5-disubstituted 2,4-dihydro-1,2,3-triazole-3-thiones is proposed.These heterocycles are obtained by the action of primary amines, aralhydrazines or aroylhydrazines on the thiosemicarbazones of esters.These last compounds are prepared by action of chlorhydrates of iminoesters on thiosemicarbazide in dimethylformamide.These thiosemicarbazones react also with strong acids, acid anhydrides and chlorides; by thermolysis and they give 2-amino-1,3,4-thiadiazole derivatives.Also, two derivatives of 1,2,4-triazolo-1,3,4-thiadiazole have been prepared.

THE SYNTHESIS AND CYCLISATIOM OF THIOACYLATED DIAMINOGUANIDINES

The thiobenzoylation of 1,2-diaminoguanidine yields 1-amino-2-thioaroylamidoguanidines which are isolable as their stable hydrazones.They are unaffected by alkalis, but are cyclised by mineral acids, with loss of ammonia, to hydrazones of 2-aryl-5-hydrazino-1,3,4-thiadiazoles, or with elimination of hydrazine, to the appropriate 2-amino-5-aryl-1,3,4-thiadiazoles.The action of acetic anhydride effects the same ring-closures, yielding the corresponding acetylated products. 1,2-Diamino-3-phenylguanidine undergoes a comparable series of reactions.