232935-04-5

Usage

Heterocyclic aromatic organic compound

1H-Indazole, 3-(2-furanyl)-1-(phenylmethyl)is a compound that contains a ring structure with alternating single and double bonds, and at least one atom in the ring is a heteroatom (an atom other than carbon or hydrogen).

Furan ring

The compound contains a furan ring, which is a five-membered ring with one oxygen atom.

Phenylmethyl group

The compound contains a phenylmethyl group, which is a benzene ring attached to a methyl group (a carbon atom with three hydrogen atoms).

Pharmacological activities

Indazoles, including 1H-Indazole, 3-(2-furanyl)-1-(phenylmethyl)-, have been found to have a range of pharmacological activities, such as anticancer, antimicrobial, and anti-inflammatory properties.

Potential drug candidate

The specific substitution pattern on the indazole core in 1H-Indazole, 3-(2-furanyl)-1-(phenylmethyl)may make it a potential candidate for drug discovery and development in the pharmaceutical industry.

New treatments

Research on 1H-Indazole, 3-(2-furanyl)-1-(phenylmethyl)- may lead to the identification of new treatments for various medical conditions.

Upstream product

• 6630-33-7 ortho-bromobenzaldehyde 
• 100-39-0 benzyl bromide 
• 3878-19-1 3-(furan-2-yl)-1H-indazole 
• 66607-27-0 3-iodoindazole 
• 13331-23-2 fur-2-ylboronic acid 
• 205643-28-3 N-benzyl-3-iodo-1H-indazole 
• 271-44-3 benzimidazole 

Downstream Products

• 205643-03-4 1-benzyl-3-(5-formyl-furan-2-yl)indazole 
• 205643-09-0 1-Benzyl-3-[5-(tert-butyl-dimethyl-silanyloxymethyl)-furan-2-yl]-1H-indazole 
• 849330-91-2 [5-(1-benzyl-1H-indazol-3-yl)-tetrahydro-furan-2-yl]methanol 

Relevant academic research and scientific papers

Preparation method of indazole and application of indazole in medicine synthesis

The invention belongs to the field of chemicals, and relates to a preparation method of indazole and an application of the indazole in medicine synthesis. The invention discloses a preparation method of indazole and an application of the indazole in synthesizing 1H-indazole-3-carboxylic acid, lonidamine, a compound 8, a compound 9, a compound 10, axitinib, YD-3, YC-1 and similar substances thereof.

Copper(I) Oxide-Mediated Cyclization of o-Haloaryl N-Tosylhydrazones: Efficient Synthesis of Indazoles

An efficient synthesis of indazoles from readily accessible E/Z mixtures of o-haloaryl N-tosylhydrazones has been developed. The thermo-induced isomerization of N-tosylhydrazones is discussed. A series of valuable indazole derivatives are prepared in good yields, and the method has been successfully applied to the synthesis of the bioactive compounds, lonidamine, AF-2785, axitinib, YC-1 and YD-3.

COMPOUNDS, COMPOSITIONS AND METHODS

The present invention provides methods and pharmaceutical compositions for inhibiting expressions of HIF and HIF regulated genes, inhibiting angiogenesis, inducing cell cycle arrest in tumor cells, and treating cell proliferating diseases or conditions.

Suzuki-type cross-coupling reaction of 3-iodoindazoles with aryl boronic acids: A general and flexible route to 3-arylindazoles

This paper describes a Suzuki Type cross coupling reaction of 3- iodoindazoles with aryl and heteroaryl boronic acids as a general route to 3- arylindazoles. The coupling reaction is illustrated by the preparation of new aryl- or heteroarylindazoles 7. Scope and limitation of the method are outlined. The coupling reaction works best on a 1-substituted indazole nucleus. The usefulness of the reaction is illustrated by a short practical synthesis of YC-1, a pharmacological agent potentially useful for the treatment of cardiovascular diseases or erectile dysfunction.