23309-52-6

Upstream product

• 24721-26-4 4-chlorochalcone 
• 141-97-9 ethyl acetoacetate 
• 22966-22-9 (E)-1-(4-chlorophenyl)-3-phenyl-2-propen-1-one 
• 65043-08-5 ethyl 4-diethoxyphosphoryl-3-oxobutanoate 
• 956-04-7 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 
• 98-86-2 acetophenone 

Downstream Products

• 933769-89-2 6-cyclohexylamido-3-phenyl-5-p-chlorophenylcyclohex-2-enone 
• 30726-33-1 3-p-Chlorphenyl-5-phenyl-1-cyclohexen 
• 26380-13-2 1-Phenyl-5-(p-chlorphenyl)-cyclohexanon-3 
• 1140253-62-8 4-(4-chlorophenyl)-6-phenyl-4,5-dihydro-2H-indazol-3-ol 
• 1161082-21-8 4-(4-chlorophenyl)-2,6-diphenyl-4,5-dihydro-2H-indazol-3-ol 
• 1190880-51-3 C₂₁H₁₈ClNO₂ 
• 1206729-96-5 2-amino-5-(4-chlorophenyl)-5,6-dihydro-7-phenylquinazolin-4-ol 
• 1290639-94-9 7-(4-chlorophenyl)-9-phenyl-1,4-diazaspiro[4.5]deca-9-ene-6-ethyl carboxylate 
• 1464082-64-1 (±)-4-(4-chlorophenyl)-2-(4-nitrophenyl)-6-phenyl-4,5-dihydro-2H-indazol-3-ol 
• 933769-95-0 6-(4-Chloro-phenyl)-2-oxo-4-phenyl-cyclohex-3-enecarboxylic acid (2-chloro-acetyl)-cyclohexyl-amide 
• 127143-10-6 ethyl 6-(4-chlorophenyl)-1-(2-cyanoethyl)-2-oxo-4-phenyl-3-cyclohexene-1-carboxylate 
• 17303-31-0 1-Phenyl-3-oxo-5-(p-chlorphenyl)-cyclohexen-⁽¹⁾ 

Relevant academic research and scientific papers

Design, synthesis and molecular docking study of some substituted 4,5-dihydro-2H-indazole derivatives as potential anti-inflammatory agents

A new series of 4,5-dihydro-2H-indazoles was synthesized and evaluated for anti-inflammatory activity using formalin-induced paw edema and turpentine oil-induced granuloma pouch bioassays. In addition, the inhibitory activity of cyclooxygenase, ulcerogenic effect, and acute toxicity (ALD50) values were also determined. Compounds 10, 13, 15, 16, 18 and 22 were proved to display distinctive anti-inflammatory profiles with a fast onset of action. They revealed super GI safety profile and are well tolerated by the experimental animals with high safety margin (ALD50 > 300 mg/Kg). The same active compounds exhibited moderate to powerful selectivity profile towards the inhibition of COX-2 enzyme. Docking poses for the most active compounds separately in the active site of human COX-2 enzyme were also obtained.

1H and 13C NMR spectral study of some 3-aryl-5r-aryl-6t-carbethoxycyclohex-2-enones - A study of four-bond 1H-1H couplings

Nine 3-aryl-5r-aryl-6t-carbethoxycyclohex-2-enones 2a-2i have been synthesized. For all these compounds, 1H and 13C NMR spectra have been recorded. For two compounds, 2D spectra have been recorded. The spectral data suggest that thes

Activated fly ash catalyzed facile synthesis of novel spiro imidazolidine derivatives as potential antibacterial and antifungal agents

An array of novel spiro imidazolidine derivatives was synthesized in dry media and was screened for their anti-microbial activities. Structure-activity relationship results revealed that compounds 22, 23 against P.aeruginosa, 24 against S.aureus, 24, 25 against K.pneumonia, 27 against S.aureus, β-H.streptococcus, 29 against M.luteus, K.pneumonia, 29, 30 against P.vulgaris exhibited excellent antibacterial activity at a minimum inhibitory concentration (MIC) value of 6.25 μg/mL. Compound 23 against M.gypseum, 25, 29 against Candida 6 and 29, 30 against C.albicans revealed excellent antifungal activity at a MIC value of 6.25 μg/mL.

Synthesis, spectral analysis, and in vitro microbiological evaluation of ethyl 7,9-diaryl-1, 4-diazaspiro[4.5]dec-9-ene-6-carboxylates as a new class of antibacterial and antifungal agents

A series of novel ethyl 7,9-diaryl-1,4-diazaspiro[4.5]dec-9-ene-6- carboxylates was synthesized by the reaction of ethyl 4,6-diaryl-2-oxocyclohex- 3-ene-1-carboxylates with ethylenediamine in the presence of p-toluenesulfonic acid without a solvent under focused microwave irradiation. The title compounds were screened for their antimicrobial activities against a spectrum of clinically isolated microorganisms.

Microwave assisted rapid and efficient. synthesis of new 3-ethoxy-4,6-diaryl-4,5- Dihydro-2,1-benzisoxazoles

A simple, extremely fast and efficient synthesis of new 3- ethoxy-4,6-diaryl-4,5-dihydro2,l-benzisoxazoles has been achieved under microwave irradiation.

A simple and practical method for the synthesis of 2-amino-5,6-dihydro-5,7- diarylquinazolin-4-ols

(Chemical Equation Presented) We report an efficient and new method of synthesis of 2-amino-5,6-dihydro-5,7-diarylquinazolin-4-ols by the reaction of substituted cyclohexenones with guanidine hydrochloride in presence of NaOEt. The reactions are with 50-72% yield. All the synthesized compounds are characterized using IR, NMR and CHN analysis.

Synthesis and characterization of 4,6-diaryl-4,5-dihydro-2H-indazol-3-ols and 4,6-diaryl-2-phenyl-4,5-dihydro-2H-indazol-3-ols - A new series of fused indazole derivatives

A novel class of 4,6-diaryl-4,5-dihydro-2H-indazol-3-ols and 4,6-diaryl-2-phenyl-4,5-dihydro-2H-indazol-3-ols is synthesized and characterized by melting point, elemental analysis, MS, FT-IR, 1H and 13C NMR, D2O exchanged 1H NMR, and two-dimensional HSQC spectra.

Highly Efficient Mechanochemical Reactions of 1,3-Dicarbonyl Compounds with Chalcones and Azachalcones Catalyzed by Potassium Carbonate

Under the high-speed vibration milling conditions, K20CO 3 was found to be a very efficient catalyst for the solvent-free Michael reactions of 1,3-dicarbonyl compounds with chalcones and azachalcones. In most cases, conventional side

Michael addition catalyzed by potassium hydroxide under ultrasound

Michael addition of chalcone with active methylene compound such as diethyl malonate, nitromethane and ethyl acetoacetate catalyzed by potassium hydroxide in anhydrous ethanol results Michael adducts in 75-98% yield under ultrasound irradiation in 25-90 m

Synthesis of Ethyl 5-Aryl-2-oxo-7-phenyl-1,2,3,4,4a,5-hexahydroquinoline-4a-carboxylates

The addition of ethyl 6-aryl-4-phenyl-2-oxo-3-cyclohexene-1-carboxylates 1a-e to acrylonitrile in the presence of aqueous sodium hydroxide is studied.The products 2a-e are transformed to the corresponding 2-oxo-1,2,3,4,4a,5-hexahydroquinolines 3 by heatin