233253-68-4Relevant articles and documents
Asymmetric synthesis of thymine nucleoside analogues based on the isochroman core
Len, Christophe,Violeau, Bruno
, p. 4835 - 4838 (2007/10/03)
Diastereoisomeric analogues of d4T having an isochroman core as the glycone moiety have been prepared in seven steps. Starting from phthalaldehyde, two chiral centres analogous to the α/β anomers of D/L sugars were created. The first was obtained enantiom
1,3-Dihydrobenzo[c]furan nucleoside analogues: Additional studies of the thymine derivative
Egron, David,Perigaud, Christian,Gosselin, Gilles,Aubertin, Anne-Marie,Faraj, Abdesslem,Selouane, Majid,Postel, Denis,Len, Christophe
, p. 4473 - 4475 (2007/10/03)
The detailed study of the 1,3-dihydrobenzo[c]furan derivative of thymine is reported. The lack of anti-HIV activity of this compound in cell culture experiments is shown to be related to the inability of the corresponding 5′-triphosphate derivative to int
Simple and stereoselective syntheses of nucleoside analogues with a benzo[c]furan glycone moiety
Ewing, David F.,Fahmi, NourEddine,Mackenzie, Grahame,Pranzo, Alessandra
, p. 559 - 563 (2007/10/03)
A series of d4T analogues have been synthesised in which the 2',3'- didehydro-2',3'-dideoxyribose moiety is replaced by a benzo[c]furan core. A simple strategy has been developed to access a range of compounds for biological screening. In addition, a ster