91463-82-0

Basic information

• Product Name: (1R)-5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine
• CAS NO: 91463-82-0
• Molecular Formula: C₁₇H₁₉NO
• Molecular Weight: 253.3389
• Mol File: 91463-82-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 369.5°C at 760 mmHg
• Flash Point: 109°C
• Density: 1.064g/cm³
• Vapor Pressure: 1.18E-05mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: (1R)-5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine(CAS DataBase Reference)
• NIST Chemistry Reference: (1R)-5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine(91463-82-0)
• EPA Substance Registry System: (1R)-5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine(91463-82-0)

Safety Data

• Hazardous Substances Data: 91463-82-0(Hazardous Substances Data)

Usage

General Description

(1R)-5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine is a chemical compound with a complex molecular structure. It belongs to the class of benzoxazocine derivatives and is a chiral molecule with a specific stereochemical configuration. (1R)-5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine has potential applications in pharmacology and medicinal chemistry, as it exhibits unique biological activity and can be used as a scaffold for the development of novel pharmaceutical agents. Research on this compound is ongoing to explore its potential therapeutic uses and mechanism of action.

Upstream product

• 23327-57-3 nefopam hydrochloride 
• 85-52-9 2-Benzoylbenzoic acid 
• 22103-85-1 2-benzoylbenzoyl chloride 
• 24833-47-4 2-benzoyl-N-(2-hydroxyethyl)-N-methylbenzamide 
• 60725-36-2 2-[{2-[hydroxyl(phenyl)methyl]benzyl}(methyl)amino]ethanol 
• 13669-70-0 nefopam 
• 18409-76-2 2-(1-phenyl-2,3-dihydro-1H-isoindol-2-yl)ethanol 
• 84940-28-3 1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine-5-carbonitrile 
• 17494-19-8 2,3-dihydro-9b-phenyloxazolo<2,3-a>isoindol-5(9bH)-one 

Downstream Products

• 129356-73-6 (+/-)-nefopam methiodide 
• 23327-57-3 nefopam hydrochloride 
• 13831-42-0 2-[(2-benzylbenzyl)(methyl)amino]ethanol 
• 60725-36-2 2-[{2-[hydroxyl(phenyl)methyl]benzyl}(methyl)amino]ethanol 
• 119-61-9 benzophenone 
• 66091-32-5 (1R,5S)/(1S,5R)-nefopam N-oxide 
• 66091-32-5 (1R,5R)/(1S,5S)-nefopam N-oxide 
• 129356-74-7 Nefopam trideuteriomethioiodide 
• 129356-74-7 Nefopam trideuteriomethioiodide 
• 865-50-9 iodomethane-d3 

Relevant articles and documents

Enantiomer resolution of nefopam hydrochloride, a novel analgesic: A study by liquid chromatography and circular dichroism spectroscopy

Nefopam, a potent analgesic, has been completely resolved into enantiomers on a preparative scale by low-pressure liquid chromatography on swollen, microcrystalline triacetylcellulose. The enantiomerically pure hydrochlorides were prepared from the base, and the circular dichroism spectra of the free base and the hydrochloride are reported.

Investigation of maltodextrin-based synergistic system with amino acid chiral ionic liquid as additive for enantioseparation in capillary electrophoresis

The combined use of chiral ionic liquids (ILs) and chiral selectors in capillary electrophoresis (CE) to establish a synergistic system has proven to be an effective approach for enantioseparation. In this article, tetramethylammonium-L-arginine, a kind of amino acid chiral IL, was applied to investigate its potential synergistic effect with maltodextrin in CE enantioseparation. The established maltodextrin-based synergistic system showed markedly improved enantioseparations compared with the single maltodextrin system. Parameters such as the chiral IL concentration, maltodextrin concentration, buffer pH, applied voltage, and capillary temperature were optimized. Satisfactory enantioseparation of the five studied drugs, including nefopam, duloxetine, ketoconazole, cetirizine, and citalopram was achieved in 50 mM Tris-H3PO4 buffer solution (pH 3.0) containing 7.0% (m/v) maltodextrin and 60 mM tetramethylammonium-L-arginine. In addition, the chiral configuration of tetramethylammonium-L-arginine was also investigated to demonstrate the existence of a synergistic effect between chiral ILs and maltodextrin.

A PROCESS FOR THE RESOLUTION OF NEFOPAM

A process for increasing the optical purity of a mixture of enantiomers of nefopam uses a substantially single enantiomer of a O,O-diaroyltartaric acid as a resolving agent, via a bisnefopam salt of the acid. This salt is new.