23360-63-6Relevant academic research and scientific papers
Organocatalyzed [2+2] Cycloaddition Reactions between Quinone Imine Ketals and Allenoates
Liu, Teng,He, Chixian,Wang, Fan,Shen, Xiang,Li, Yongqin,Lang, Man,Li, Guijun,Huang, Chao,Cheng, Feixiang
, p. 518 - 526 (2020/10/12)
A new cycloaddition reaction of quinone imine ketals (QIKs), which could be utilized to the construction of functionalized azaspirocyclics under mild conditions, is described. This transformation involved a [2+2] cycloaddition reaction between QIKs and allenoates catalyzed by DABCO, and then treatment with 1 N HCl in one-pot. The strategy could provide a practical route to access azetidine-fused spirohexadienones in good to excellent yields and with high E -selectivity.
Engaging Allene-Derived Zwitterions in an Unprecedented Mode of Asymmetric [3+2]-Annulation Reaction
Sankar, Muthukumar G.,Garcia-Castro, Miguel,Golz, Christopher,Strohmann, Carsten,Kumar, Kamal
supporting information, p. 9709 - 9713 (2016/08/10)
Catalytic addition of chiral phosphine, that is, (R)- or (S)-SITCP, to an α-substituted allene ester generated a zwitterionic dipole. Under optimized reaction conditions, this dipole could engage isatine-derived N-Boc-ketimines in a novel mode of [3+2] an
NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES FOR THE TREATMENT OF CANCER
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Page/Page column 36-37, (2012/07/31)
The present invention provides compounds of formula or pharmaceutically acceptable salts, esters or stereoisomers thereof, wherein R1 to R4, A and Y have the meanings given herein, as well as methods for making those compounds and their use as medicament, in particular as medicament for the treatment of cancer.
NOVEL 4-AMINO-N-HYDROXY-BENZAMIDES AS HDAC INHIBITORS FOR THE TREATMENT OF CANCER
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Page/Page column 72-74, (2012/08/07)
The present invention provides HDAC inhibitors of formula (I), or pharmaceutically acceptable salts, esters or stereoisomers thereof, wherein R1 to R4, A and Y have the meanings given herein, as well as methods for making those compounds and their use as medicament, in particular as medicament for the treatment of cancer
Conformations of diester triphenyl-phosphonium ylides with an ylidic ester or keto and ester ylidic groups
Castaeda, Fernando,Silva, Paul,Bunton, Clifford A.,Garland, Maria Teresa,Baggio, Ricardo
experimental part, p. o319-o323 (2011/10/05)
The structures of three related keto diester and diester ylides, namely diethyl 3-oxo-2-(triphenylphosphoranylidene)glutarate, C27H 27O5P, (I), diethyl 3-oxo-2-(triphenylphosphoranylidene) glutarate acetic acid monosolvate
Preparation and Characterization of [5-13C]-(2S,4R)-Leucine and [4-13C]-(2S,3S)-Valine - Establishing Synthetic Schemes to Prepare Any Site-Directed Isotopomer of L-Leucine, L-Isoleucine and L-Valine
Siebum, Arjan H. G.,Woo, Wei Sein,Lugtenburg, Johan
, p. 4664 - 4678 (2007/10/03)
In this paper a chemo-enzymatic method has been developed that gives access to any isotopomer of the essential amino acids isoleucine and valine. The method gives the correct introduction of the second chiral center in (2S,3S)-isoleucine and allows for discrimination between the two prochiral methyl groups in valine as shown by the preparation of (2S,3S)-[4- 13C] valine. For the preparation of (2S)-leucine in any isotopomeric form, the O'Donnell method to prepare optically active amino acids has been used. The protected glycine scaffold used in this method has been prepared by a strategy that allows access to any isotopomeric form. The preparation of [5-13C]-(2S,4R)-leucine shows that the O'Donnell method in combination with the Evans method to obtain chiral 2-methylpropyl iodide leads to a good discrimination between the two prochiral methyl groups. The O'Donnell strategy for the preparation of α-amino acids is preferred over other methods since the reaction conditions are mild, the chiral auxiliary can be easily recovered and the optically active product can be easily separated. For the preparation of isotopically enriched valine and isoleucine the O'Donnell method is not suitable, because the alkyl substituents involved have a secondary halide substituent which is sterically too hindered to give an effective reaction with the protected glycine. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
Structural and conformational analysis of 2-triphenylphosphoranylidene succinic acid derivatives by 1H, 13C and 31P one and two dimensional NMR spectroscopy and molecular modelling
Bacaloglu, Radu,Blasko, Andrei,Bunton, Clifford A.,Cerichelli, Giorgio,Castaneda, Fernando,Rivera, Enrique
, p. 965 - 972 (2007/10/02)
The structure and conformation of 2-triphenylphosphoranylidenesuccinic acid derivatives have been studied by 1H, 13C and 31P NMR spectroscopy, in various solvents and at variable temperatures.In 2-triphenylphosphoranylidenesuccinic anhydride (1) the confo
