233600-78-7

Basic information

• Product Name: N-[4-[(Trifluoroacetyl)aMino]benzoyl]-L-glutaMic Acid DiMethyl Ester
• Synonyms: N-[4-[(Trifluoroacetyl)aMino]benzoyl]-L-glutaMic Acid DiMethyl Ester;RXRWKOBMLFNNBA-NSHDSACASA-N
• CAS NO: 233600-78-7
• Molecular Formula: C₁₆H₁₇F₃N₂O₆
• Molecular Weight: 390.3111896
• Mol File: 233600-78-7.mol

Chemical Properties

• Boiling Point: 536.3±50.0 °C(Predicted)
• Appearance: /
• Density: 1.366±0.06 g/cm3(Predicted)
• Solubility: Methanol
• PKA: 9.52±0.70(Predicted)
• CAS DataBase Reference: N-[4-[(Trifluoroacetyl)aMino]benzoyl]-L-glutaMic Acid DiMethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-[(Trifluoroacetyl)aMino]benzoyl]-L-glutaMic Acid DiMethyl Ester(233600-78-7)
• EPA Substance Registry System: N-[4-[(Trifluoroacetyl)aMino]benzoyl]-L-glutaMic Acid DiMethyl Ester(233600-78-7)

Safety Data

• Hazardous Substances Data: 233600-78-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N-[4-[(Trifluoroacetyl)amino]benzoyl]-L-glutamic Acid Dimethyl Ester is used as an intermediate in the synthesis of Folic Acid (F680300) for its role in synthesizing DNA, conducting DNA repair, and methylating DNA by acting as a cofactor in biological reactions involving folate. This makes it a crucial component in the development of medications and supplements targeting DNA-related processes and overall cellular health.

Upstream product

• 404-26-2 4-(trifluoroacetamido)benzoic acid 
• 23150-65-4 L-glutamic dimethyl ester hydrochloride 
• 540-37-4 p-aminoiodobenzene 
• 126063-08-9 2,2,2-trifluoro-N-(4-iodophenyl)acetamide 
• 56-86-0 L-glutamic acid 

Downstream Products

• 2544-29-8 N⁽²⁾-acetylfolic acid 
• 59-30-3 folic acid 
• 4271-30-1 N-(4-aminobenzoyl)-L-glutamic acid 

Relevant articles and documents

The synthesis of folic acid, multiply labelled with stable isotopes, for bio-availability studies in human nutrition

Two different methods for the synthesis of folic acid, which are suitable for the incorporation of compounds multiply labelled with stable isotopes, are described. The first method is based on the use of a novel reductive amination to link 2-acetyIamino-4-hydroxy-6-formylpteridine withp-aminobenzoyl-L-glutamic acid. The second method is based on the penultimate formation of an amide bond between Ar-2-acetyl-Ar-10-trifluoroacetyIpteroic acid and dimethyl L-glutamate. Both methods have been used to transform [13C6]aniline into folic acid, labelled with [13C6] in the p-aminobenzoate moiety, and [3,3,4,4-2H4]-L-glutamic acid into folic acid, labelled with [2H4] in the glutamate moiety. Doubly labelled [13C6,2H 4]-p-aminobenzoyl-L-glutamate has also been prepared by the former method.