2338-25-2

Usage

InChI:InChI=1/C8H3Cl2F3N2/c9-3-1-5-6(2-4(3)10)15-7(14-5)8(11,12)13/h1-2H,(H,14,15)

Upstream product

• 5348-42-5 4,5-Dichloro-1,2-phenylenediamine 
• 6641-64-1 4,5-dichloro-2-nitroaniline 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 41035-29-4 4,7-Dibromo-5,6-dichloro-2-trifluoromethylbenzimidazole 
• 1473415-05-2 6-chloro-5-(3,4-dichlorophenyl)-2-trifluoromethylbenzimidazole 
• 1360442-47-2 C₁₅H₉Cl₂F₃N₂ 
• 1360442-54-1 C₁₆H₈Cl₂F₆N₂ 
• 1360442-60-9 C₁₅H₈Cl₂F₃N₃O₂ 
• 1360442-51-8 C₁₆H₈Cl₂F₆N₂ 
• 1360442-57-4 C₁₅H₈Cl₂F₃N₃O₂ 
• 1360442-65-4 C₁₅H₁₀Cl₂F₃N₃ 
• 1360442-56-3 C₁₅H₈Cl₂F₃N₃O₂ 

Relevant academic research and scientific papers

Synthesis and antiparasitic activity of 2-(Trifluoromethyl)benzimidazole derivatives

2-(Trifluoromethyl)benzimidazole derivatives substituted at the 1-, 5-, and 6-positions have been synthesized and in vitro tested against the protozoa Giardia lamblia, Entamoeba histolytica, and the helminth Trichinella spiralis. Results indicate that all the compounds tested are more active as antiprotozoal agents than Albendazole and Metronidazole. One compound (20) was as active as Albendazole against T. spiralis. These compounds were also tested for their effect on tubulin polymerization and none inhibited tubulin polymerization.

Synthesis of novel halogenated heterocycles based on o‐phenylenediamine and their interactions with the catalytic subunit of protein kinase ck2

Protein kinase CK2 is a highly pleiotropic protein kinase capable of phosphorylating hundreds of protein substrates. It is involved in numerous cellular functions, including cell viability, apoptosis, cell proliferation and survival, angiogenesis, or ER‐stress response. As CK2 activity is found perturbed in many pathological states, including cancers, it becomes an attractive target for the pharma. A large number of low‐mass ATP‐competitive inhibitors have already been developed, the majority of them halogenated. We tested the binding of six series of halogenated heterocyclic ligands derived from the commercially available 4,5‐dihalo‐benzene‐1,2‐diamines. These ligand series were selected to enable the separation of the scaffold effect from the hydrophobic interactions attributed directly to the presence of halogen atoms. In silico molecular docking was initially applied to test the capability of each ligand for binding at the ATP‐binding site of CK2. HPLC‐derived ligand hydrophobicity data are compared with the binding affinity assessed by low‐volume differential scanning fluorimetry (nanoDSF). We identified three promising ligand scaffolds, two of which have not yet been described as CK2 inhibitors but may lead to potent CK2 kinase inhibitors. The inhibitory activity against CK2α and toxicity against four reference cell lines have been determined for eight compounds identified as the most promising in nanoDSF assay.

Method of treating parastic protozoa with substituted benzimidazoles

The present invention relates to the use of benzimidazoles of the formula (I) STR1 in which X1, X2, X3, X4, R3 and R5 are described herein and these compounds are agents for combatting parasitic protozoa, in particular coccidia.