234093-22-2

Upstream product

• 7464-46-2 p-nitrophenyl p-methoxybenzoate 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 123-11-5 4-methoxy-benzaldehyde 
• 2373-89-9 4,4'-dimethoxychalcone 
• 696-62-8 para-iodoanisole 
• 16308-14-8 4-methoxy(diacetoxyiodo)benzene 
• 75059-30-2 3,5-bis(4-methoxiphenyl)-1H-pyrazole 

Relevant academic research and scientific papers

Transition-Metal-Free N-Arylation of Pyrazoles with Diaryliodonium Salts

A new synthetic method was developed for the N-arylation of pyrazoles using diaryliodonium salts. The transformation does not require any transition-metal catalyst and provides the desired N-arylpyrazoles rapidly under mild reaction condition in the presence of aqueous ammonia solution as a mild base without the use of inert atmosphere. The chemoselectivity of unsymmetric diaryliodonium salts was also explored with large number of examples.

Estrogen receptor modulators

Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating estrogen receptor activity. Thus, the compounds of the present invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.

Halogen-substituted triarylpyrazoles: potential estrogen receptor-alpha selective radiopharmaceuticals

Halogen-substituted analogs of a pyrazole ligand for the estrogen receptor have been synthesized. These analogs retain much of the affinity preference of the parent ligand for the estrogen receptor alpha sybtype (ERα) vs beta subtype (ERβ).