234430-04-7

Upstream product

• 626-39-1 1,3,5-trisbromobenzene 
• 67-64-1 acetone 
• 67973-33-5 3,5-dibromobenzoic acid ethyl ester 
• 676-58-4 methylmagnesium chloride 
• 618-58-6 3,5-dibromobenzoic acid 

Downstream Products

• 234430-03-6 1,3-bis(N-tert-butyl-N-(oxylamino))-5-(1'-methyl-1'-[2''-(S)-methylbutoxy]ethyl)benzene 
• 234430-06-9 1,3-bis[N-tert-butyl-N-(hydroxyamino)]-5-{1'-methyl-1'-[2''-(S)-methylbutoxy]ethyl}benzene 
• 1333113-26-0 C₁₇H₁₈Br₂O 
• 1333113-33-9 C₂₄H₃₁BrO₇ 
• 1333113-37-3 C₂₃H₂₉BrO₆ 
• 1333113-45-3 C₃₁H₃₇BrO₁₀ 
• 1333113-22-6 C₂₃H₂₉BrO₆ 
• 1541198-67-7 3-bromo-5-(2-hydroxypropan-2-yl)benzaldehyde 
• 1541198-66-6 (S)-ethyl 3-amino-3-(3-bromo-5-(2-hydroxypropan-2-yl)phenyl)propanoate 
• 1541198-69-9 (S)-3-amino-3-(3-bromo-5-(2-hydroxypropan-2-yl)phenyl)propanoic acid 
• 1541198-68-8 ethyl 3-amino-3-(3-bromo-5-(2-hydroxypropan-2-yl)phenyl)propanoate 
• 234430-05-8 1,3-dibromo-5-{1'-methyl-1'-[2''-(S)-methylbutoxy]ethyl}benzene 

Relevant academic research and scientific papers

BETA AMINO ACID DERIVATIVES AS INTEGRIN ANTAGONISTS

Disclosed herein are novel pharmaceutical agents which are useful as integrin receptor antagonists that mediate the pathologic processes of angiogenesis and fibrosis and as such are useful in pharmaceutical compositions and in methods for treating conditions mediated by these integrins by inhibiting or antagonizing these integrins. The novel pharmaceutical agents include those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods and intermediates useful for making the pharmaceutical agents and methods of using the pharmaceutical agents are also provided.

Design, synthesis and in vivo anti-hyperglycemic activity of gem-dimethyl-bearing C-glucosides as SGLT2 inhibitors

A series of gem-dimethyl-bearing C-glucosides were designed and synthesized as SGLT2 inhibitors, with anhydrous aluminum chloride-mediated Friedel-Crafts alkylation to construct the gem-dimethyl functionality being the key step. The in vivo anti-hyperglycemic activity was evaluated with mice oral glucose tolerance test (OGTT), and all the synthesized compounds showed significant but less potent anti-hyperglycemic activity than the positive control dapagliflozin.

Field-induced ferrimagnetic state in a molecule-based magnet consisting of a CoII ion and a chiral triplet bis(nitroxide) radical

We present the synthesis, crystal structure, and temperature and field dependence of the magnetic properties of a new molecule-based magnet, [Co(hfac)2]7bull;BNO* (1), where hfac = 1,1,1,5,5,5- hexafluoroacetylacetonato and BNO* is the chiral t