234751-02-1Relevant articles and documents
Theoretical and experimental design of atypical kinase inhibitors: Application to p38 MAP kinase
McClure, Kim F.,Abramov, Yuriy A.,Laird, Ellen R.,Barberia, John T.,Cai, Weiling,Carty, Thomas J.,Cortina, Santo R.,Danley, Dennis E.,Dipesa, Alan J.,Donahue, Kathleen M.,Dombroski, Mark A.,Elliott, Nancy C.,Gabel, Christopher A.,Han, Seungil,Hynes, Thomas R.,LeMotte, Peter K.,Mansour, Mahmoud N.,Marr, Eric S.,Letavic, Michael A.,Pandit, Jayvardhan,Ripin, David B.,Sweeney, Francis J.,Tan, Douglas,Tao, Yong
, p. 5728 - 5737 (2005)
Mimics of the benzimidazolone nucleus found in inhibitors of p38 kinase are proposed, and their theoretical potential as bioisosteres is described. A set of calculated descriptors relevant to the anticipated binding interaction for the fragments 1-methyl-
Design, synthesis and biological evaluation: 5-amino-1h-pyrazole-1-carbonyl derivatives as fgfr inhibitors
Zhang, Yan,Yu, Niefang
, p. 1330 - 1341 (2020/10/06)
Background: Fibroblast growth factors (FGFs) and their high affinity receptors (FGFRs) play a major role in cell proliferation, differentiation, migration, and apoptosis. Aberrant FGFR signaling pathway might accelerate development in a broad panel of mal
Synthesis of Aminofuran-Linked Benzimidazoles and Cyanopyrrole-Fused Benzimidazoles by Condition-Based Skeletal Divergence
Hsu, Wei-Shun,Tsai, Min-Huan,Barve, Indrajeet J.,Yellol, Gorakh S.,Sun, Chung-Ming
, p. 492 - 499 (2017/07/15)
A condition-based skeletal divergent synthesis was explored to achieve skeletal diversity in two component condensation reaction. Cyanomethyl benzimidazole was reacted with α-bromoketone under thermal conditions to furnish 2-aminofuranyl-benzimidazoles, w
