23501-59-9Relevant academic research and scientific papers
A facile and selective high yield synthesis of symmetric dialkyl-substituted methylenebisphosphonic acids
Stepinski, Dominique C.,Herlinger, Albert W.
, p. 2683 - 2690 (2002)
Symmetric P,P′-dialkyl partial esters of methylenebisphosphonic acid were prepared in high yield and high selectivity from the corresponding acid chloride via a facile two-step, one-pot process. The newly developed synthesis, which does not require chromatographic or acid-base extractive purification, offers substantial advantages over previously used procedures.
Facile high yielding synthesis of symmetric esters of methylenebisphosphonic acid
Stepinski, Dominique C,Nelson, Derek W,Zalupski, Peter R,Herlinger, Albert W
, p. 8637 - 8645 (2007/10/03)
The 1H-tetrazole catalyzed coupling of methylenebis(phosphonic dichloride), CH2(POCl2)2, with primary alkyl, cyclic secondary alkyl, aromatic, and silicon- and fluorine-containing alcohols selectively affords symmetric P,P′-dialkyl partial esters as well as homoleptic and mixed tetraesters. Two partial ester intermediates, methylenebis(2-ethylhexyl phosphonic chloride) and 2-ethylhexyl methylenebisphosphonic trichloride, were observed by 1H- and 31P NMR spectroscopy in the esterification of CH2(POCl2)2 with 2-ethyl-1-hexanol.
