235092-30-5

Upstream product

• 24134-12-1 1,2-dimethyl-1H-imidazole-5-carbaldehyde 
• 24134-09-6 5-bromo-1,2-dimethyl-1H-imidazole 
• 122334-37-6 4-chloro-N-methoxy-N-methylbenzamide 
• 1739-84-0 1,2-dimethyl-1H-imidazole 
• 122-01-0 4-chloro-benzoyl chloride 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 235092-26-9 (4-chloro-phenyl)-(2,3-dimethyl-3H-imidazol-4-yl)-methanol 

Downstream Products

• 235092-34-9 [5-(4-chloro-benzoyl)-1-methyl-1H-imidazol-2-yl]-acetic acid ethyl ester 
• 1600563-61-8 (4-chlorophenyl)(2,4-dichloro-3-phenylquinolin-6-yl)(1,2-dimethyl-1H-imidazol-5-yl)methanol 
• 1600565-89-6 4-chloro-6-((4-chlorophenyl)(1,2-dimethyl-1H-imidazol-5-yl)(hydroxy)methyl)-3-phenylquinoline-2-carbonitrile trifluoroacetate 

Relevant academic research and scientific papers

HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt

The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.

Synthesis and anti-inflammatory activity of some 1-methyl-5-(4-substituted benzoyl)imidazole-2-acetates

1-Methyl-5-(4-X-benzoyl)imidazole-2-acetates were synthesized and tested for anti-inflammatory activity. Tolmetin and aspirin were used as reference drugs. The most active compound against carrageenan-induced oedema in rat hindpaw was a 4-chlorobenzoyl de