23575-73-7Relevant academic research and scientific papers
Microwave-assisted synthesis, DFT theoretical study and biological activities evaluation of two phosphonylated m-toluidine derivatives
Haddadi, Ines,Hellal, Abdelkader,Kirouani, Imene,Layaida, Houdheifa,Bensouici, Chawki
, (2021/12/02)
An easy and efficient microwave-assisted method has been developed for the synthesis of two phosphonylated molecules: α-aminophosphonic acid (MTA) and α-aminophosphonate ester (MTE). To achieve these, we have synthesized the products from m-toluidine, und
Catalyst free one-pot synthesis of α-aminophosphonates in aqueous ethyl lactate
Gao, Ge,Chen, Meng-Nan,Mo, Li-Ping,Zhang, Zhan-Hui
, p. 528 - 532 (2019/01/04)
An highly efficient and environmentally friendly process for the synthesis of α-aminophosphonates has been devised, through a one-pot three-component condensation of various aldehydes, amines and triethyl phosphate in water-ethyl lactate under ultrasonic
A Green Approach to the Synthesis of α-Amino Phosphonate in Water Medium: Carbene Insertion into the N-H Bond by Cu(I) Catalyst
Ramakrishna, Kankanala,Thomas, Jisha Mary,Sivasankar, Chinnappan
, p. 9826 - 9835 (2016/11/02)
Synthesis of amino phosphonates is more important owing to their significant applications in the biological systems. There are few methods already known in the literature to make these molecules; however, known methods have their own disadvantages. In this regard, synthesis of different kinds of amino phosphonates have been achieved via phosphonate substituted carbene insertion into the N-H bond of aniline catalyzed by readily available copper salt under mild reaction conditions in water. In order to find an efficient catalyst for carbene insertion reaction in neat water, a large number of transition metal catalysts were screened, and we found that the [Cu(CH3CN)4]ClO4 was the best catalyst under employed reaction conditions. Using this environmentally benign methodology (copper catalyzed reaction in water), a large number of biologically important amino phosphonates have been synthesized, isolated (37 examples), and characterized using standard analytical and spectroscopic techniques.
ZrOCl2·8H2O: An efficient catalyst for one-pot synthesis of α-amino phosphonates under solvent-free conditions
Bhanushali, Mayur J.,Nandurkar, Nitin S.,Jagtap, Sachin R.,Bhanage, Bhalchandra M.
experimental part, p. 845 - 859 (2009/08/15)
A highly efficient protocol has been developed for the three-component reaction of an amine, an aldehyde, and diethyl phopshite catalyzed by ZrOCl2·8H2O, an environmentally friendly catalyst, at ambient temperature. The catalyst exhibited remarkable activ
An efficient synthesis of anilinobenzylphosphonates
Ha,Nam
, p. 1143 - 1148 (2007/10/02)
An efficient one-pot synthesis of anilinobenzylphosphonates was achieved from the reaction of aniline, benzaldehyde, and dialkylphosphite in the presence of BF3·OEt2 as a catalyst
