235780-25-3Relevant academic research and scientific papers
Transition-Metal-Free Defluorosilylation of Fluoroalkenes with Silylboronates
Gao, Pan,Wang, Guoqiang,Xi, Longlong,Wang, Minyan,Li, Shuhua,Shi, Zhuangzhi
, p. 1009 - 1014 (2019)
Silylated fluoroalkenes are important synthetic intermediates with complementary reactivity, which play a key role in the construction of natural products, pharmaceuticals, and manmade materials. Converting the normally highly stable fluoroalkenes into si
Process for Production of 2-(Substituted Phenyl)-3,3,3-Trifluoropropene Compound
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Page/Page column 7, (2010/07/04)
There is provided a novel process for production of a 2-(substituted phenyl)-3,3,3-trifluoropropene. Disclosed is a process for production of a 2-(substituted phenyl)-3,3,3-trifluoropropene compound represented by the formula (7) or a salt thereof The process comprises reacting a compound represented by the formula (1) (X is an alkyl group, etc.) with a compound represented by the formula (2) (Y is a halogen atom, etc.) in the presence of a catalyst represented by the formula (3) (M is an ion of a metal belonging to Group 10 on the elementary periodic table which has an oxidation state number of 1 to 8; G is a unidentate or multidentate ligand; L is a phosphine compound represented by the formula (4) which is bound to the center metal M or is a carbene selected from those represented by the formulae (5) and (6), provided that L's may be same as or different from one another when a is 2 to 5; A represents a univalently or multivalently charged anion; b represents an integer of 1 to 3; a represents an integer of 1 to 5·b; c represents 0 or an integer of 1 to 4·b; and n represents an integer of 1 to 6).
A novel and convenient synthetic method for producing α-(trifluoromethyl)styrenes (3)
Pan, Rui-Qi,Liu, Xing-Xin,Deng, Min-Zhi
, p. 167 - 170 (2007/10/03)
The Suzuki-type coupling reaction of arylboronic acids (1) with 2-bromo-3,3,3-trifluoropropene (2) in the presence of a catalytic amount of dichlorobis(triphenylphosphine)palladium {PdCl2(PPh3)2} and a base can easily give α-(trifluoromethyl)styrenes (3) in good yields. It was also found that 1,2-dibromo-3,3,3-trifluoropropane (4) underwent dehydrobromination in the presence of KOH, and subsequently, palladium-catalyzed cross-coupling with 1 to directly afford 3 in a one pot manner in excellent yields.
