235786-03-5Relevant articles and documents
Asymmetric synthesis of BB-3497 - A potent peptide deformylase inhibitor
Pratt, Lisa M.,Beckett, R. Paul,Davies, Stephen J.,Launchbury, Steven B.,Miller, Andrew,Spavold, Zoe M.,Todd, Richard S.,Whittaker, Mark
, p. 2585 - 2588 (2007/10/03)
By screening a library of metalloenzyme inhibitors, the N-formyl-hydroxylamine derivative BB-3497 was identified as a potent inhibitor of Escherichia coli peptide deformylase with antibacterial activity both in vitro and in vivo. The homochiral synthesis of BB-3497, involving a novel asymmetric Michael addition reaction is described.