235789-25-0

Upstream product

• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 
• 119987-21-2 methyl α-styryl-α-diazoacetate 
• 98-86-2 acetophenone 
• 41167-58-2 2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid methyl ester 
• 539-44-6 N-4-methylphenylhydrazine 
• 82417-84-3 methyl 2-chloro-2-(4-methylphenyl-hydrazono)acetate 
• 536-74-3 phenylacetylene 
• 39847-99-9 (Z)-methyl 2-hydroxy-4-oxo-4-phenylbut-2-enoate 

Downstream Products

• 176230-81-2 4-chloro-5-phenyl-1-p-tolyl-1H-pyrazole-3-carboxylic acid methyl ester 
• 62160-78-5 5-phenyl-1-p-tolyl-1H-pyrazole-3-carboxylic acid 

Relevant academic research and scientific papers

When hydrazonoyl chlorides meet terminal alkynes: Regioselective copper(I)-catalysed click sequential reactions to 5-substituted pyrazoles

In the presence of catalytic amounts of copper(I) salts, terminal alkynes underwent the formation of copper(I) acetylides that enabled their nucleophilic addition onto hydrazonoyl chlorides followed by spontaneous cyclisation of the resulting alkynylhydrazone intermediate. This sequential reaction sequence was exploited as a facile and regioselective synthesis of 1,3,5-substituted pyrazoles. A catalytic cycle has been proposed accounting for the observed results.

Diacylhydrazines derivative containing indole skeleton as well as preparation method and application thereof

The invention discloses a diacylhydrazines derivative containing an indole skeleton as well as a preparation method and application thereof. A structure of the diacylhydrazines derivative containing the indole skeleton disclosed by the invention is shown in a formula: the formula (1) is shown in the description, wherein R1 is selected from -H and -F; R2 is selected from -H and -Br; R3 is selectedfrom -H, -Cl and -I; R4 is selected from -CH3, -Cl, -H, -F and -CF3. A synthetic method of the diacylhydrazines derivative has the advantages of simple process, less steps, lower cost, high efficiencyand convenience and has good universality, and moreover, the diacylhydrazines derivative can be produced in batch.

When aryldiazonium salts meet vinyl diazoacetates: A cobalt-catalyzed regiospecific synthesis of N-arylpyrazoles

A cobalt-catalyzed C-N bond formation between aryl diazonium salts and vinyl diazoacetates has been developed under relatively mild conditions. The N-arylpyrazoles have been prepared in moderate to high yields in a regiospecific way.

Synthesis and herbicidal activity of 1,5-diarylpyrazole derivatives

A series of diarylpyrazolecarboxylates and carboxamides were prepared, and their herbicidal activities were investigated. Some of these compounds showed noticeable pre-emergent herbicidal activities against various kinds of weeds. Among the synthesized co