23596-02-3

Usage

InChI:InChI=1/C16H15NO2/c1-12(18)14-5-7-15(8-6-14)17-11-13-3-9-16(19-2)10-4-13/h3-11H,1-2H3/b17-11+

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 99-92-3 p-aminobenzophenone 
• 100-19-6 (4-nitrophenyl)ethanone 
• 105-13-5 4-Methoxybenzyl alcohol 

Downstream Products

• 115848-62-9 3-(4-acetophenyl)-2-(p-methoxyphenyl)thiazolidin-4-one 
• 38131-68-9 4-(4-dimethylaminobenzylidene)aminoacetophenone 
• 2286-29-5 ethyl 2-cyano-3-(4-methoxyphenyl)prop-2-enoate 
• 7443-25-6 dimethyl 2-(4-methoxybenzylidene)malonate 
• 2826-26-8 2-(4-methoxyphenylmethylene)malononitrile 
• 1370225-47-0 (4-{1-[(7-chloro-quinolin-4-yl)-hydrazono]-ethyl}-phenyl)-(4-methoxy-benzylidene)-amine 
• 405103-36-8 1-(4-((4-methoxybenzyl)amino)phenyl)ethan-1-one 

Relevant academic research and scientific papers

Synthesis, characterization and theoretical study in gaseous and solid phases of the imine 4-Acetyl-N-(4-methoxybenzylidene)aniline

In the present paper we describe the synthesis and characterization of the Schiff's base or imine 4-Acetyl-N-(4-methoxybenzylidene)aniline (1), which provided experimental support for the theoretical calculations. The imine was characterized by infrared s

Synthesis, Antiproliferative and Cytotoxic Activities, DNA Binding Features and Molecular Docking Study of Novel Enamine Derivatives

Novel enamine derivatives were synthesized from the reaction of lactone and chalcones and their antiproliferative and cytotoxic activities against six cancer cell lines (e. g., HeLa, HT29, A549, MCF7, PC3 and Hep3B) and one normal cell lines (e. g., FL) were investigated along with their mode of interactions with CT-DNA. Most of the enamine derivatives with IC50 values of 86–168 μM demonstrated much stronger antiproliferative activity than the starting molecules against the cancer cells. While, among the enamine derivatives, four compounds displayed higher cytotoxic potency than the control drugs (5-fluorouracil and cisplatin) against the Hep3B cell lines, these compounds did not exhibit any significant toxicity against normal cells, FL. The UV/VIS spectral data suggest that eight compounds cause hypochromism with a slight bathochromic shift (～6 nm), indicating that they bind to the DNA by way of an intercalative or minor groove binding mode. The binding constants of the compounds are in the range of 0.1×103 M?1–2.3×104 M?1. The antiproliferative activity of studied enamine derivatives could possibly be due to their DNA binding as well as their cytotoxic properties. In addition to these assays, the chalcones and enamine derivatives were investigated by molecular docking to calculate the synergistic effect of antiproliferative activities against six human cancer cell lines.

Visible-Light Photocatalytic Synthesis of Amines from Imines via Transfer Hydrogenation Using Quantum Dots as Catalysts

CdSe/CdS core/shell quantum dots (QDs) can be used as stable and highly active photoredox catalysts for efficient transfer hydrogenation of imines to amines with thiophenol as a hydrogen atom donor. This reaction proceeds via a proton-coupled electron transfer (PCET) from the QDs conduction band to the protonated imine followed by hydrogen atom transfer from the thiophenol to the α-aminoalkyl radical. This precious metal free transformation is easy to scale up and can be carried out by a one-pot protocol directly from aldehyde, amine, and thiophenol. Additional advantageous features of this protocol include a wide substrate scope, high yield of the amine products, extremely low catalyst loading (0.001 mol %), high turnover number (105), and the mild reaction conditions of using visible light or sun light at room temperature in neutral media.

Visible-light-responsive multielectron redox catalysis of lacunary polyoxometalates induced by substrate coordination to their lacuna

We describe herein the efficient visible-light-responsive polyoxometalate-based multielectron photoredox catalysis induced by in situ coordination of alcohols to the lacuna of TBA4H4[γ-SiW10O36] (I, TBA=tetra-n-butylammonium). The coordination of alcohols to the lacuna of I generated a new highest occupied molecular orbital as the electron donor level and enabled the visible-lightresponsive multielectron transfer from alcohols to I, which could be utilized for aerobic alcohol oxidation and onepot synthesis of N-arylimines starting from nitroarenes and primary alcohols.

Design, synthesis and in vitro antimalarial evaluation of new quinolinylhydrazone derivatives

A series of novel quinolinylhydrazones (5a-f) was synthesized by the condensation reaction of 2,6-diaryl-substituted piperidin-4-ones (4a-f) with 7-chloro-4-hydrazinoquinoline (2). Novel quinolinylhydrazones containing Shiff bases 8a-f and 11a-f were obta

Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs

The GPR30 agonist probe G-1 and structural analogs were efficiently synthesized using multicomponent or stepwise Sc(iii)-catalyzed aza-Diels-Alder cyclization. Optimization of solvent and reaction temperature provided enhanced endo-diastereoselectivity.

Chemoselectivity in reactions of an α-diazo-β-diketone with some conjugative double-bond systems

Reactions of 2-diazo-1,3-diphenylpropane-1,3-dione with α,β-unsaturated aldehydes and ketones, and keto-imines, in refluxing anhydrous toluene indicate that benzoyl(phenyl)ketene, which is generated by the thermal Wolff rearrangement of 2-diazo-1,3-diphen

Synthesis of Some New &β-Lactams, 4-Thiazolidinones and Pyrazolines

N-Arylidene-p-aminoacetophenone (I) and N-arylidene-4'-aminochalcones (V) have been converted into a series of substituted β-lactams (III) and 4-thiazolidinones (IV), and pyrazolines (VI, VII) respectively. p-Chloroacetamidoacetophenone (II) has also been converted into series of substituted 4'-piperidino/morpholinoacetoamidochalcones (X) which undergo cyclization on treatment with hydrazine, phenylhydrazine or thiourea to pyrazolines (XI, XII) and pyrimidine-2-thiones (XIII) respectively.The antibacterial and antifungal activities of the compounds have been determined.