23597-25-3

Upstream product

• 106-44-5 p-cresol 
• 933-88-0 ortho-toluoyl chloride 
• 118-90-1 ortho-methylbenzoic acid 
• 73686-46-1 2-methylbenzoic acid 2-pyridinyl ester 
• 57139-25-0 N-methoxy-2-methylbenzamide 

Downstream Products

• 147029-79-6 (2-Hydroxy-5-methyl-phenyl)-o-tolyl-methanone 
• 1026436-81-6 3-Isocyanato-6-methyl-4-o-tolyl-chromen-2-one 
• 137711-79-6 6-Methyl-2-oxo-4-o-tolyl-2H-chromene-3-carboxylic acid 
• 137711-64-9 6-Methyl-2-oxo-4-o-tolyl-2H-chromene-3-carboxylic acid ethyl ester 
• 794513-65-8 2-methyl-benzoic acid 4-methyl-2-(2-methyl-benzoyl)-phenyl ester 

Relevant academic research and scientific papers

Electrodimerization of N-Alkoxyamides for Zinc(II) Catalyzed Phenolic Ester Synthesis under Mild Reaction Conditions

An electrochemical On-Off method for phenolic ester synthesis from N-alkoxyamides has been reported. This one-pot protocol begins with rapid and selective electrodimerization of the amide using n-Bu4NI (TBAI) as an electrocatalyst. The reaction proceeds further in the absence of current via Zn catalyzed C?N bond activation of the amide dimer followed by its coupling with phenol to form the ester. The present methodology is ligand-free and takes place under mild reaction conditions. This transformation incorporates a wide variety of phenols and amide substrates leading to the formation of functionalized esters highlighting its versatility. (Figure presented.).

Transesterification of (hetero)aryl esters with phenols by an Earth-abundant metal catalyst

Readily available and inexpensive Earth-abundant alkali metal species are used as efficient catalysts for the transesterification of aryl or heteroaryl esters with phenols which is a challenging and underdeveloped transformation. The simple conditions and the use of heterogeneous alkali metal catalyst make this protocol very environmentally friendly and practical. This reaction fills in the missing part in transesterification reaction of phenols and provides an efficient approach to aryl esters, which are widely used in the synthetic and pharmaceutical industry.

A convenient procedure for the esterification of benzoic acids with phenols: a new application for the Mitsunobu reaction

The Mitsunobu reaction was found to be a convenient and effective method for the esterification of various benzoic acids with differentially functionalized phenols producing the corresponding phenyl esters in good to excellent yields.

Synthesis of 3-ureido derivatives of coumarin and 2-quinolone as potent Acyl-CoA: Cholesterol acyltransferase inhibitors

Novel 3-ureido derivatives of 4-phenylcoumarin and 4-phenyl-2-quinolone were synthesized and evaluated for acyl-CoA: cholesterol acyltransferase (ACAT)-inhibitory activity. These derivatives inhibited rat intestinal ACAT with IC50 values at the 10-8 to 10-9 M level and were found to normalize plasma cholesterol levels in cholesterol-fed rats when administered as dietary admixtures.