23600-48-8

Upstream product

• 123-30-8 4-amino-phenol 
• 155164-68-4 4,5-Dichloro-2-(4-methoxy-benzoyl)-2H-pyridazin-3-one 
• 98-95-3 nitrobenzene 
• 100-07-2 4-methoxy-benzoyl chloride 
• 100-65-2 N-Phenylhydroxylamine 
• 13664-49-8 N-phenyl-p-methoxybenzohydroxamic acid 
• 201230-82-2 carbon monoxide 
• 696-62-8 para-iodoanisole 
• 7465-88-5 4-methoxy-N-phenylbenzamide 

Downstream Products

• 90446-42-7 N-(4-Hydroxy-3,5-bis-pyrrolidin-1-ylmethyl-phenyl)-4-methoxy-benzamide 
• 321691-41-2 C₁₄H₁₁NO₃ 
• 321691-03-6 4-amino-N-(4-methylbenzoyl)-2-chlorophenol 
• 321947-10-8 4-amino-N-(4-methoxybenzoyl)-2-chlorophenol 

Relevant academic research and scientific papers

Redox-Neutral Selenium-Catalysed Isomerisation of para-Hydroxamic Acids into para-Aminophenols

A selenium-catalysed para-hydroxylation of N-aryl-hydroxamic acids is reported. Mechanistically, the reaction comprises an N?O bond cleavage and consecutive selenium-induced [2,3]-rearrangement to deliver para-hydroxyaniline derivatives. The mechanism is studied through both 18O-crossover experiments as well as quantum chemical calculations. This redox-neutral transformation provides an unconventional synthetic approach to para-aminophenols.

A new series of aryl sulfamate derivatives: Design, synthesis, and biological evaluation

Steroid sulfatase (STS) has recently emerged as a drug target for management of hormone-dependent malignancies. In the present study, a new series of twenty-one aryl amido-linked sulfamate derivatives 1a-u was designed and synthesized, based upon a cycloh

Novel 3/4-((Substitutedbenzamidophenoxy)methyl)-N-hydroxybenzamides/propenamides and its use

The present invention relates to novel 3/4-((substituted benzamidophenoxy) methyl) -N-hydroxy benzamide/propenamide, as a histone deacetylase (HDAC) inhibitor, and to an anticancer composition comprising the same as an active ingredient. More specifically

Pd-catalyzed chemoselective carbonylation of aminophenols with iodoarenes: Alkoxycarbonylation vs aminocarbonylation

Palladium-catalyzed chemoselective carbonylation of aminophenols with iodoarenes was realized by changing ligand and base. 3- or 4-Aminophenols afforded esters in high yields and selectivities using 1,3-bis(diphenylphosphino)propane as the ligand and K2CO3 as the base, and gave amides in high yields and selectivities using 1,3-bis(diisobutylphosphino)propane as the ligand and DBU as the base. 2-Aminophenol only gave amides in high yields under both conditions.

2-Acylpyridazin-3-ones: Novel mild and chemoselective acylating agents for amines

2-Acyl-4,5-dichloropyridazin-3-ones served as excellent novel N-acylating reagents for amines under neutral conditions in organic solvent. They are convenient, chemoselective and easy to handle stable N-acylating reagents of amines.

Introduction of a hydroxy group at the para position and N-iodophenylation of N-arylamides using phenyliodine(III) bis(trifluoroacetate)

The reaction of anilides with phenyliodine(III) bis(trifluoroacetate) (PIFA) in trifluoroacetic acid (TFA), TFA-CHCl3, or hexafluoroisopropyl alcohol (HFIP) is described. When the acyl group of the anilide is highly electronegative, such as trifluoroacetyl, or the phenyl group is substituted with an electron-withdrawing group, the 4-iodophenyl group is transferred from PIFA to the amide nitrogen to afford acetyldiarylamines. On the other hand, when the acyl group contains an electron-donating function, such as 4-methoxyphenyl, or the phenyl group is substituted with an electron-donating group, a trifluoroacetoxy group is transferred to the para position of the anilide aromatic ring. This group is hydrolyzed during workup to produce the corresponding phenol.

Synthesis and Antiarrhythmic and Parasympatholytic Properties of Substituted Phenols. 2. Amides

Thirty amides patterned after the antiarrhythmic drug changrolin were synthesized and their antiarrhythmic and parasympatholytic activities were assessed. There was no correlation between antiarrhythmic and parasympatholytic activities. Several of the ami