236115-77-8

Upstream product

• 90852-19-0 (1α,2β,3α,4β,6β)-4,6-Diazido-1,2,3-cyclohexantriol-triacetat 
• 236115-70-1 6-azido-6-deoxy-2,3,4-tri-O-benzyl-1-phenylthio-β-D-glucopyranoside 
• 236115-71-2 6-(4-methylbenzenesulfonate)-phenyl-1-thio-β-D-glucopyranoside 
• 236115-72-3 6-azido-6-deoxy-1-phenylthio-β-D-glucopyranoside 
• 90899-14-2 (1α,2β,3α,4β,6β)-4,6-Diazido-1,2,3-cyclohexantriol 
• 100-39-0 benzyl bromide 
• 2037-48-1 2-deoxystreptamine 
• 2936-70-1 (2R,3S,4S,5R,6S)-2-Hydroxymethyl-6-phenylsulfanyl-tetrahydro-pyran-3,4,5-triol 
• 236115-61-0 [(1S,2S,3R,4S,6R)-2-acetoxy-4,6-diazido-3-hydroxy-cyclohexyl] acetate 
• 864862-14-6 (1R,2S,3S,4R,6S)-1-O-(6'-azido-6'-deoxy-2',3',4'-tri-O-benzyl-α-D-glucopyranosyl)-2,3-diacetoxy-4,6-diazido-cyclohexanol 

Downstream Products

• 31077-71-1 4-O-(6-amino-6-deoxy-α-D-glucopyranosyl)-2-deoxystreptamine 
• 864954-68-7 1-O-(6'-azido-6'-deoxy-2',3',4'-tri-O-benzyl-α-D-glucopyranosyl)-3-O-(6''-azido-6''-deoxy-2'',3'',4''-tri-O-benzyl-α-L-glucopyranosyl)-4,6-diazido-cyclohexan-1,2,3-ol 

Relevant academic research and scientific papers

Synthesis of a library of stereo- and regiochemically diverse aminoglycoside derivatives

A library of forty modified aminoglycosides was prepared in which the configuration and regiochemistry of two or three rings was widely varied. The library was based around three core ring systems: the 2-deoxystreptamine ring system found in the natural products, and both enantiomers of (1R*,2R*,4R*,5R*)-2,5-diamino-cyclohexane-1,4-diol and (1R*,3R*,4R*,6R*)-4,6-diaminocyclohexane-1,3-diol. In each case, the core was modified by glycosylation with one or two sugar rings. The absolute configuration of the sugar substituents (D or L), the configuration of the anomeric centres (α or β), and the regiochemical arrangement of the amine(s) were varied. The Royal Society of Chemistry 2005.

NEW AMINOGLYCOSIDE COMPOUNDS AND DERIVATIVES THEREOF

New amino glycoside compounds or derivatives thereof having at least one sugar moiety and which comprise two or more cyclic structures capable of forming “charmed” structural features at physiological pH, and which have binding affinities for RNA and protein structures and may be used as therapeutic or screening or diagnostic agents and the like.

Design and synthesis of new aminoglycoside antibiotics containing neamine as an optimal core structure: Correlation of antibiotic activity with in vitro inhibition of translation

The structure and activity of the pseudodisaccharide core found in aminoglycoside antibiotics was probed with a series of synthetic analogues in which the position of amino groups was varied around the glucopyranose ring. The naturally occurring structure