2362-16-5

Usage

Uses

Used in Pharmaceutical Industry:
1,2-BIS(CHLOROMETHYL)-4,5-DIMETHYLBENZENE is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows for the creation of complex organic molecules that can be utilized in the development of new drugs and medications.
Used in Dye Industry:
In the dye industry, 1,2-BIS(CHLOROMETHYL)-4,5-DIMETHYLBENZENE is used as a precursor in the production of dyes. Its reactivity and ability to form stable compounds make it a valuable component in the creation of a wide range of dyes with different properties and applications.
Used in Polymer Industry:
1,2-BIS(CHLOROMETHYL)-4,5-DIMETHYLBENZENE is also used as a monomer in the polymer industry. It can be polymerized to form polymers with specific characteristics, such as high thermal stability and chemical resistance, which are essential in various industrial applications.
Safety Precautions:
It is important to handle 1,2-BIS(CHLOROMETHYL)-4,5-DIMETHYLBENZENE with care, as it is toxic and can cause irritation to the skin, eyes, and respiratory system. Proper safety measures should be in place when working with 1,2-BIS(CHLOROMETHYL)-4,5-DIMETHYLBENZENE, including the use of protective clothing, gloves, and a well-ventilated workspace to minimize exposure and potential health risks.

InChI:InChI=1/C10H12Cl2/c1-7-3-9(5-11)10(6-12)4-8(7)2/h3-4H,5-6H2,1-2H3

Upstream product

• 50-00-0 formaldehyd 
• 95-47-6 o-xylene 
• 110-88-3 1,3,5-Trioxan 
• 7647-01-0 hydrogenchloride 
• 95-93-2 1,2,4,5-tetramethylbenzene 

Downstream Products

• 60070-05-5 1,2-bis(hydroxymethyl)-4,5-dimethylbenzene 
• 10230-61-2 1,2-dimethyl-4,5-di(mercaptomethyl)benzene 
• 95-47-6 o-xylene 
• 27742-96-7 5,6,11,12,-tetrahydro-2,3,8,9-tetramethyldibenzocyclooctatetraene 
• 18779-88-9 1,1'-(1,2-ethanediyl)bis-(2,4,5-trimethylbenzene) 
• 25445-42-5 4,5-dimethylbenzene-1,2-dicarbaldehyde 
• 119197-53-4 6,7-dimethyl-3-phenyl-3-isochromanyl phenyl ketone 
• 856685-92-2 1,2-Dimethyl-4,5-bis-(4-nitro-phenoxymethyl)-benzene 
• 627102-17-4 C₂₂H₂₄N₂S₂ 
• 856685-83-1 C₂₆H₂₆O₆ 
• 1000292-80-7 13b,13c-bis(4-methoxyphenyl)-2,3,9,10-tetramethyl-5,7,12,13b,13c,14-hexahydro-5a,6a,12a,13a-tetraazabenzo[5,6]azuleno[2,1,8-ija]benzo[f]azulene-6,13-dione 
• 1000292-81-8 13b,13c-di(4-methoxyphenyl)-1,2,3,4,8,9,10,11-octa-methyl-5,7,12,13b,13c,14-hexahydro-5a,6a,12a,13a-tetraazabenzo[5,6]azuleno[2,1,8-ija]benzo[f]azulene-6,13-dione 
• 127797-35-7 2-phenyl-2-iodo-5,6-dimethyl-1,3-dihydro-2-telluraindene 
• 127818-80-8 2-phenyl-5,6-dimethyl-1,3-dihydro-2-telluraindene tetraphenylborate 

Relevant academic research and scientific papers

Synthesis, crystal structure, binding properies of a noncyclic crown-type receptor derived from diethoxycarbonyl glycoluril

A novel noncyclic crown-type diethoxycarbonyl glycoluril derivative receptor was synthesised and its crystal structure was obtained. The study of its binding behaviour towards neutral guests showed that it can bind hydroquinone, resorcinol and catechol.

An experimental and theoretical study on imidazolium-based ionic liquid promoted chloromethylation of aromatic hydrocarbons

The chloromethylation of aromatic hydrocarbons proceeded efficiently using the reusable imidazolium-based ionic liquid as promoter. Mild reaction conditions, enhanced rates, improved yields, recyclability of ionic liquids, and reagents' reactivity which is different from that in conventional organic solvents are the remarkable features observed in ionic liquids. The ionic liquids were recycled in three subsequent runs with no decrease in activity. In addition, the results of calculations with the Gaussian 98 suite of program are in good accordance with the experimental outcomes.

Efficient dichloromethylation of some aromatic hydrocarbons catalyzed by a new ionic liquid [C12minPEG800]br under homogeneous catalysis in aqueous media

A series of new imidazolium-type ionic liquids based on polyethylene glycol have been prepared. The new recyclable temperature-dependant phase-separation system comprised of [C12minPEG800]Br and methylcyclohexane was also developed and successfully applied to the dichloromethylation of some aromatic hydrocarbons to prepare dichloromethyl-substituted hydrocarbons in excellent yields. The ionic liquid could be excellent recycled without any apparent loss of catalytic activity and little loss of weight even after 8 times recycling.

An inexpensive and efficient synthetic method for the preparation of pyromellitic dianhydride promoted by ionic liquid

In this article, pyromellitic dianhydride could be successfully obtained in 76.7% total yield by an aerobic oxidation of 1,4-bis(chloromethyl)-2,5- dimethylbenzene or 1,5-bis(chloromethyl)-2,4- dimethylbenzene catalyzed by VO(acac)2/Cu(2-Eth)2/DABCO in [hmim]OTf and a subsequent dehydration of pyromellitic acid upon heating with acetic anhydride. The starting materials including 1,2-bis(chloromethyl)-4,5-dimethylbenzene were prepared by dichloromethylation of their corresponding xylene catalyzed by [C12mim]Br in aqueous media. ARKAT USA, Inc.

Identification of alkylarene chloromethylation products using gas-chromatographic retention indices

Gas-chromatographic retention indices on standard nonpolar polydimethylsiloxane stationary phases allow identification of products formed by known organic reactions even without using mass-spectrometric data. The efficiency of this approach was demonstrated by the example of identification of previously uncharacterized chloromethyl derivatives of alkylarenes, including structural isomers of compounds containing several chloromethyl groups, directly in reaction mixtures. Chromatographic analysis of such reaction mixtures allows identification of positional isomers of the starting alkylarenes even when they are present simultaneously. The retention indices were determined for the first time for more than 50 alkyl-(chloromethyl)arenes, by-products of chloromethylation, and chloromethyl derivatives of the simplest alkyl phenyl ketones. Nauka/Interperiodica 2007.

The first immobilisation of glycoluril-based molecular clips on silica gel and alumina

The first example of immobilisation of some glycoluril-based molecular clips, which are good receptors for dihydroxybenzenes, on silica gel and alumina is described. 4,4'-Bis(methoxyphenyl)glycoluril was used as the base scaffold for the synthesis of mole

[emim]BF4-promoted chloromethylation of aromatic hydrocarbons

The chloromethylation of aromatic hydrocarbons proceeded efficiently using the reusable ionic liquid [emim]BF4 as promoter. The reactions were completed in 5 h at 70°C with good yields and easy workup. Copyright Taylor & Francis Group, LLC.

Interpretation of retention indices in gas chromatography for establishing structures of isomeric products of alkylarenes radical chlorination

By an example of previously uncharacterized products obtained by alkylarenes radical chlorination was demonstrated that combination of various interpretation methods applied to the retention indices (RI) in the gas chromatography on the standard nonpolar phases (comparison of RI of products and initial compounds, characteristics of succession of the chromatographic elution of the structural isomers with the use of estimation of molecular dynamic parameters, application of the additive schemes to RI calculation, and using of structural analogy CH3?Cl for testing the results obtained) permitted unambiguous identification of the structure even without data of mass spectrometry.