23662-66-0Relevant academic research and scientific papers
A supporting france for cloth as the starting material of the preparation method (by machine translation)
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Paragraph 0007; 0023; 0029, (2017/12/06)
The invention discloses a method for supporting france for cloth starting material N - ((3 R, 4 R) - 4 - methyl - 1 - benzyl - 3 - piperidinyl) - N - methyl - 7 - paratoluene sulfonyl - 7 H - pyrrolo [2, 3 - D] pyrimidine - 4 - amine (I) synthetic method, specific steps are as follows: to 4 - methyl pyridine as the starting material, with the benzyl chloride undergo nucleophilic substitution by the 4 - methyl - 1 - phenylmethyl - pyridine hydrochloride, under the action of the sodium borohydride reduction reaction, borohydrite - oxidation reaction, hydroxy oxidation, the introduction of the reductive amination of the stereo selectivity of the two chiral center, through a readily available and inexpensive chiral acid (L - DTTA) splitting, to obtain optically pure intermediates (3 R, 4 R) - (1 - benzyl - 4 - methyl - piperidin - 3 - yl) - methylamine, and finally with the 4 - chloro pyrrolo pyrimidine condensation is obtained. The whole method raw materials are easy, simple operation, after treatment is easy, and the cost is low. (by machine translation)
Acentric nonlinear optical N-benzyl stilbazolium crystals with high environmental stability and enhanced molecular nonlinearity in solid state
Kim, Pil-Joo,Jeong, Jae-Hyeok,Jazbinsek, Mojca,Kwon, Seong-Ji,Yun, Hoseop,Kim, Jong-Taek,Lee, Yoon Sup,Baek, In-Hyung,Rotermund, Fabian,Guenter, Peter,Kwon, O-Pil
experimental part, p. 444 - 451 (2012/01/06)
We have developed a new cation core structure, N-benzyl stilbazolium nonlinear optical chromophore with a non-polar benzyl group to achieve acentric molecular ordering in the crystalline state. New N-benzyl stilbazolium crystal, BP3 (N,N-dimethylamino-N′-2,5-dimethylbenzyl-stilbazolium p-toluenesulfonate), exhibits an acentric crystal structure with the monoclinic P21 phase with a large macroscopic optical nonlinearity of 540 times the powder second harmonic generation efficiency of urea at the non-resonant wavelength of 1.9 m. Compared to conventional rod-shaped N-alkyl stilbazolium crystals, an enhanced hyperpolarizability of the chromophores β0 in the solid state can be utilized in bent-shaped N-benzyl stilbazolium crystals. This is attributed to the decreased inter-chromophore interactions due to the larger chromophore-chromophore separation induced by the bulky and bent-shaped N-benzyl group, so-called site-isolation effect. Moreover, by introducing the non-polar dimethylbenzyl group, BP3 crystals show a high environmental stability: they exhibit almost one order of magnitude smaller solubility in water than conventional stilbazolium crystals and also do not form a hydrated centrosymmetric phase even if crystallized in water-containing solvents. We have grown good optical quality crystals large enough for optical characterization. With as-grown BP3 crystals without additional polishing and cutting procedures we have demonstrated THz generation by optical rectification using 180 fs pulses at the pump wavelength of 836 nm.
Zwitterionic chromophores and macromolecules containing such chromophores
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, (2008/06/13)
The invention disclosed relates to functionalized zwitterionic chromophores of structural formula III and III′. Wherein A is a linear or branched alkyl group having up to 20 carbon atoms and the desired functional groups, B is hydrogen, alkyl, aryl, halo, heterocyclic, alkoxy or nitro groups at 2, 3, 5 or 6 positions on the pyridine ring, C is hydrogen, aryl or a linear or branched alkyl group at 2′, 3′, 5′ or 6′ positions on the benzene ring, which has up to 70 carbon atoms and contains the desired functional group, D is a linear or branched alkyl, aryl or substituted aryl group, which has up to 70 carbon atoms and contains the desired functional group, R is C1-C4 alkyl or aryl, and m is an integer of from 0 to 4.
Development of a scaleable route for the production of cis-N-benzyl-3-methylamino-4-methylpiperidine
Brown Ripin, David H.,Abele, Stefan,Cai, Weiling,Blumenkopf, Todd,Casavant, Jeffrey M.,Doty, Jonathan L.,Flanagan, Mark,Koecher, Christian,Laue, Klaus W.,McCarthy, Keith,Meltz, Cliff,Munchhoff, Mike,Pouwer, Kees,Shah, Bharat,Sun, Jianmin,Teixeira, John,Vries, Ton,Whipple, David A.,Wilcox, Glenn
, p. 115 - 120 (2013/09/05)
The synthesis of cis-N-benzyl-3-methylamino-4-methylpiperidine (5) via hydroboration of tetrahydropyridine 3 followed by oxidation and reductive amination was optimized and scaled up to produce 10-kg quantities of product. Three routes to 3 were identified, and the reduction of pyridinium salt 7 was selected as the most preferable to run on-scale. The hydroboration and oxidative workup were carefully studied to optimize throughput on that transformation, as was the reductive amination.
Pyrrolo[2,3-d]pyrimidine compounds
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, (2008/06/13)
A compound of the formula wherein R1, R2 and R3 are as defined above, useful as inhibitors of protein kinases, such as the enzyme Janus Kinase 3.
