384338-20-9

Basic information

• Product Name: 1-benzyl-4-methylpiperidin-3-ol
• Synonyms: 1-benzyl-4-methylpiperidin-3-ol;4-Methyl-1-(phenylmethyl)-3-piperidinol;3-Piperidinol, 4-Methyl-1-(phenylMethyl)-;Trans-1-benzyl-4-methyl-piperidin-3-ol
• CAS NO: 384338-20-9
• Molecular Formula: C13H19NO
• Molecular Weight: 205.3
• Mol File: 384338-20-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 305.4±35.0 °C(Predicted)
• Appearance: /
• Density: 1.064
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.84±0.40(Predicted)
• CAS DataBase Reference: 1-benzyl-4-methylpiperidin-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-methylpiperidin-3-ol(384338-20-9)
• EPA Substance Registry System: 1-benzyl-4-methylpiperidin-3-ol(384338-20-9)

Safety Data

• Hazardous Substances Data: 384338-20-9(Hazardous Substances Data)

Usage

Description

1-benzyl-4-methylpiperidin-3-ol is a chemical compound with the molecular formula C16H23NO and a molecular weight of 245.36 g/mol. It is a piperidine derivative characterized by the presence of a benzyl group attached to the nitrogen atom and a methyl group on the fourth carbon of the piperidine ring. 1-benzyl-4-methylpiperidin-3-ol holds potential in the pharmaceutical domain, particularly as an opioid receptor modulator, and has been recognized for its analgesic and antipruritic properties. It is also being explored as a potential treatment for substance use disorders and for its role in the synthesis of other organic compounds. However, due to its potential psychoactive effects, it requires careful handling and usage.

Uses

Used in Pharmaceutical Industry:
1-benzyl-4-methylpiperidin-3-ol is used as an opioid receptor modulator for its potential therapeutic applications in managing pain and itching. Its interaction with opioid receptors suggests it could provide analgesic effects, making it a candidate for the development of pain relief medications.
1-benzyl-4-methylpiperidin-3-ol is also used as a potential treatment for substance use disorders, given its capacity to modulate opioid receptors, which may assist in managing withdrawal symptoms and cravings associated with opioid dependence.
Used in Chemical Synthesis:
In the field of organic chemistry, 1-benzyl-4-methylpiperidin-3-ol is utilized as a building block in the synthesis of other complex organic compounds, contributing to the development of new pharmaceuticals, agrochemicals, or other specialty chemicals.

Upstream product

• 32018-56-7 1-benzyl-4-methyl-1 ,2,3,6-tetrahydropyridine 
• 32018-96-5 1-benzyl-4-methyl-piperidin-3-one 
• 6998-30-7 methylamine acetate 
• 100-46-9 benzylamine 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 100-39-0 benzyl bromide 
• 41979-39-9 4-piperidone hydrochloride 
• 23662-66-0 1-benzyl-4-methylpyridinium chloride 
• 100-44-7 benzyl chloride 
• 108-89-4 picoline 

Downstream Products

• 923036-30-0 N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-(7-p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1354621-59-2 C₁₄H₂₂N₂ 
• 1259404-17-5 tasocitinib 
• 384338-23-2 (1-benzyl-4-methyl-piperidin-3-yl)-methyl-amine 
• 374822-48-7 C₆H₁₃NO 

Relevant articles and documents

Short enantioselective total synthesis of (+)-tofacitinib

An enantioselective total synthesis of Tofacitinib (CP-690,550), a Janus tyrosine kinase (JAK3) specific inhibitor has been achieved from the readily available 4-piperidone. Proline catalysed hydroxylation is the key step for the synthesis of enantiopure 1-benzyl-4-methylpiperidin-3-ol.

Method for preparing lactam compound

The invention relates to a preparation method of a lactam compound, and belongs to the field of medicinal chemistry. The preparation method comprises the following steps: carrying out an asymmetric hydrogenation reaction on raw materials under the action of a ruthenium catalyst and a hydrogen donor reagent, and carrying out a post treatment to obtain the target compound. The product obtained by the method is high in ee value, the method is simple and convenient, and the target compound can be easily, conveniently and efficiently obtained.

A supporting france for cloth as the starting material of the preparation method (by machine translation)

The invention discloses a method for supporting france for cloth starting material N - ((3 R, 4 R) - 4 - methyl - 1 - benzyl - 3 - piperidinyl) - N - methyl - 7 - paratoluene sulfonyl - 7 H - pyrrolo [2, 3 - D] pyrimidine - 4 - amine (I) synthetic method, specific steps are as follows: to 4 - methyl pyridine as the starting material, with the benzyl chloride undergo nucleophilic substitution by the 4 - methyl - 1 - phenylmethyl - pyridine hydrochloride, under the action of the sodium borohydride reduction reaction, borohydrite - oxidation reaction, hydroxy oxidation, the introduction of the reductive amination of the stereo selectivity of the two chiral center, through a readily available and inexpensive chiral acid (L - DTTA) splitting, to obtain optically pure intermediates (3 R, 4 R) - (1 - benzyl - 4 - methyl - piperidin - 3 - yl) - methylamine, and finally with the 4 - chloro pyrrolo pyrimidine condensation is obtained. The whole method raw materials are easy, simple operation, after treatment is easy, and the cost is low. (by machine translation)