236754-49-7 Usage
Description
Azide-PEG4-Tos is a versatile crosslinking reagent characterized by its two functional groups, which enable it to form stable covalent bonds with various molecules. The polyethylene glycol (PEG) spacer within its structure enhances solubility in aqueous media, making it suitable for a wide range of applications. The azide (N3) group is highly reactive with alkyne, BCN, and DBCO groups through Click Chemistry, resulting in the formation of a stable triazole linkage. Additionally, the tosyl group acts as an effective leaving group for nucleophilic substitution reactions, further expanding the reagent's utility in chemical and biological applications.
Uses
Used in Chemical Synthesis:
Azide-PEG4-Tos is used as a crosslinking agent for chemical synthesis, allowing the formation of stable triazole linkages between molecules through Click Chemistry. This application is particularly useful in the creation of complex molecular structures and the development of novel materials.
Used in Bioconjugation:
In the field of bioconjugation, Azide-PEG4-Tos is used as a coupling agent to link biological molecules, such as proteins, peptides, and nucleic acids, with other molecules or surfaces. The stable triazole linkage formed through Click Chemistry ensures that the bioconjugates maintain their structural integrity and functionality.
Used in Drug Delivery Systems:
Azide-PEG4-Tos is employed as a component in the design and synthesis of drug delivery systems, where it can be used to attach therapeutic agents to carriers or to modify the surface properties of drug delivery vehicles. The PEG spacer enhances solubility and biocompatibility, while the reactive groups allow for precise control over the drug release and targeting.
Used in Materials Science:
In materials science, Azide-PEG4-Tos is used as a building block for the development of novel materials with tailored properties. The reagent's ability to form stable covalent bonds and its solubility in aqueous media make it an attractive candidate for the synthesis of polymers, hydrogels, and other advanced materials with specific mechanical, optical, or electronic properties.
Used in Diagnostics and Imaging:
Azide-PEG4-Tos is utilized as a labeling agent in the field of diagnostics and imaging, where it can be used to attach detection moieties, such as fluorescent tags or radioisotopes, to biological molecules. The stable triazole linkage ensures that the labels remain attached to the target molecules, allowing for accurate detection and imaging of biological processes.
Used in Anticancer Applications:
Although not explicitly mentioned in the provided materials, Azide-PEG4-Tos could potentially be used in the development of anticancer agents, similar to the application of Gallotannin. The reagent's ability to form stable covalent bonds and its solubility in aqueous media could be exploited to create targeted drug delivery systems or to modify the properties of existing chemotherapeutic agents, potentially enhancing their efficacy and reducing side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 236754-49-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,3,6,7,5 and 4 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 236754-49:
(8*2)+(7*3)+(6*6)+(5*7)+(4*5)+(3*4)+(2*4)+(1*9)=157
157 % 10 = 7
So 236754-49-7 is a valid CAS Registry Number.
236754-49-7Relevant articles and documents
Compound for degrading TGF-beta1 through targeted ubiquitination, and preparation method and application thereof
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Paragraph 0053-0056; 0063-0065, (2020/09/20)
The invention discloses a compound (I) for targeted ubiquitination degradation of TGF-beta1. The compound (I) for degradation of TGF-beta1 through targeted ubiquitination is formed by connecting a TGF-beta1 micromolecular ligand and an E3 ubiquitin ligase
Acetylcholin esterase degradation compound as well as preparation method and application thereof
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Paragraph 0141-0144, (2020/02/10)
The invention discloses an acetylcholin esterase degradation compound as well as a preparation method and application thereof. The acetylcholin esterase degradation compound is a compound shown as a general formula Wa or Wb. According to the invention, AChE ligand and CRBN ligand are connected by adopting a proper means, and a new compound is designed and obtained, so that the degradation of the AChE can be specifically enhanced, and the purpose of treating related diseases is achieved. The compound and the pharmaceutically acceptable salt thereof can be used for preparing medicines for treating diseases, disorders or symptoms beneficial to acetylcholin esterase degradation. The AChE degradation enhancing compound has a unique induced protein degradation mechanism, only a small amount of medicine is needed, the process is similar to a catalytic reaction, the medicine with the equal molar weight is not needed, and the use dosage of the medicine and toxic and side effects can be reducedby using difunctional small molecules.
