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2-[2-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid, also known as t-Boc-N-amido-PEG5-CH2CO2H, is a heterobifunctional, PEGylated crosslinker with a carboxylic acid at one end and a Boc-protected amino group at the other. The hydrophilic PEG linker increases solubility in aqueous media, making it suitable for various biological applications.

890152-41-7

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890152-41-7 Usage

Uses

Used in Bioconjugation:
2-[2-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid is used as a crosslinker for bioconjugation, allowing the formation of stable amide bonds between the terminal carboxylic acid and primary amine groups of biomolecules in the presence of activators such as EDC or HATU.
Used in Chemical Biology and Medicinal Chemistry:
2-[2-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid is used as a building block for the synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds in chemical biology and medicinal chemistry that require ligation.
Used in Targeted Protein Degradation:
2-[2-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid is used in the synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC) molecules for targeted protein degradation.
Used in Drug Delivery Systems:
2-[2-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid can be used in the development of drug delivery systems, where the Boc-protected amino group can be deprotected under mild acidic conditions to form the free amine, allowing for the attachment of drug molecules or other targeting agents.

Check Digit Verification of cas no

The CAS Registry Mumber 890152-41-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,0,1,5 and 2 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 890152-41:
(8*8)+(7*9)+(6*0)+(5*1)+(4*5)+(3*2)+(2*4)+(1*1)=167
167 % 10 = 7
So 890152-41-7 is a valid CAS Registry Number.

890152-41-7Downstream Products

890152-41-7Relevant academic research and scientific papers

HETEROCYCLIC DERIVATIVES

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, (2020/08/13)

Compounds of the formula (I): Q1-Q2-Q3, in which Q1, Q2 and Q3 have the meanings indicated in Claim 1, degrade target proteins, and can be employed, inter alia, for the treatment of diseases such as cancer, multiple sclerosis, cardiovascular diseases, central nervous system injury and different forms of inflammation.

IRAK DEGRADERS AND USES THEREOF

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, (2019/07/10)

The present invention provides compounds, compositions thereof, and methods of using the same.

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