23705-40-0

Basic information

• Product Name: N-(sec-butyl)-4-methylbenzenesulfonamide
• Synonyms: N-(sec-butyl)-4-methylbenzenesulfonamide
• CAS NO: 23705-40-0
• Molecular Formula: C₁₁H₁₇NO₂S
• Molecular Weight: 227.32318
• Mol File: 23705-40-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 333.9°Cat760mmHg
• Flash Point: 155.7°C
• Appearance: /
• Density: 1.102g/cm³
• Vapor Pressure: 0.000133mmHg at 25°C
• Refractive Index: 1.516
• CAS DataBase Reference: N-(sec-butyl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(sec-butyl)-4-methylbenzenesulfonamide(23705-40-0)
• EPA Substance Registry System: N-(sec-butyl)-4-methylbenzenesulfonamide(23705-40-0)

Safety Data

• Hazardous Substances Data: 23705-40-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H17NO2S/c1-4-10(3)12-15(13,14)11-7-5-9(2)6-8-11/h5-8,10,12H,4H2,1-3H3

Upstream product

• 75934-48-4 (S)-(+)-N-sec-butyl-N-nitroso-4-toluenesulfonamide 
• 17425-82-0 (sec-butylamino)trimethylsilane 
• 98-59-9 p-toluenesulfonyl chloride 
• 142-96-1 dibutyl ether 
• 70-55-3 toluene-4-sulfonamide 
• 78-92-2 iso-butanol 
• 33966-50-6 SEC-BUTYLAMINE 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 27350-45-4 sec-butyl diphenylphosphinite 
• 590-18-1 (Z)-2-Butene 
• 75-16-1 methylmagnesium bromide 
• 123-38-6 propionaldehyde 
• 4104-47-6 N-sulfinyl-p-toluenesulfonamide 
• 917-54-4 methyllithium 

Downstream Products

• 92198-68-0 N-sec-butyl-N-(toluene-4-sulfonyl)-glycine 
• 2512-22-3 N-Chlor-N-sek.-butyl-toluol-p-sulfonamid 

Relevant articles and documents

An efficient method for the preparation of monoalkylated sulfonamides from unsubstituted sulfonamides and alkyl diphenylphosphinites by oxidation-reduction condensation using trimethylsilylmethyl azide

An efficient method for monoalkylation of unsubstituted sulfonamides was established by using alkyl diphenylphosphinites, sulfonamides and trimethylsilylmethyl azide and the monoalkylated sulfonamides were afforded in good yields under neutral conditions.

A Hydrazone-Based exo-Directing-Group Strategy for β C-H Oxidation of Aliphatic Amines

Described is a new hydrazone-based exo-directing group (DG) strategy developed for the functionalization of unactivated primary β C-H bonds of aliphatic amines. Conveniently synthesized from protected primary amines, the hydrazone DGs are shown to site-selectively promote the β-acetoxylation and tosyloxylation via five-membered exo-palladacycles. Amines with a wide scope of skeletons and functional groups are tolerated. Moreover, the hydrazone DG can be readily removed, and a one-pot C-H acetoxylation/DG removal protocol was also discovered. All about the DGs: A hydrazone-based exo-directing group (DG) strategy is developed for the functionalization of unactivated primary β C-H bonds of aliphatic amines. The hydrazone DGs can be conveniently installed and removed, and promote β-acetoxylation and tosyloxylation via a five-membered exo-palladacycle. PG=protecting group, Ts=4-toluenesulfonyl.

Br?nsted acid-assisted N-alkylation of sulfonamides using ethers as the alkylation reagents

N-Alkylation of sulfonamides using cyclic ethers as alkylation reagents and Br?nsted acid as a catalyst produced pyrrolidine and piperidine derivatives in good yields. When using symmetrical and unsymmetrical ethers as alkylation reagents, mono-N-alkylation of sulfonamides took place to afford the corresponding products.