23767-37-5

Upstream product

• 23766-28-1 5-(4-chlorophenyl)-2,3-dihydro-1,3,4-oxadiazole-2-thione 
• 74-88-4 methyl iodide 
• 23766-28-1 5-(4-chlorophenyl)-1,3,4-oxadiazole-2-thiol 
• 77-78-1 dimethyl sulfate 
• 75-15-0 carbon disulfide 
• 536-40-3 4-chlorobenzoic acid hydrazide 
• 74-11-3 para-chlorobenzoic acid 
• 1126-46-1 Methyl 4-chlorobenzoate 

Downstream Products

• 23767-38-6 2-methylsulphonyl-5-(4-chlorophenyl)-1,3,4-oxadiazole 
• 1711-61-1 5-(4-chlorophenyl)-3H-[1,3,4]oxadiazol-2-one 
• 861229-53-0 benzoic acid N'-[5-(4-chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-hydrazide 
• 75821-15-7 [5-(4-chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-hydrazine 
• 4469-02-7 2-(N,N-dimethylamino)-5-(4-chlorophenyl)-1,3,4-oxadiazole 

Relevant academic research and scientific papers

One-pot synthesis of 2-Alkylthio-1,3,4-oxadiazole and Bis-(1,3,4- oxadiazole-2-yl)thio alkyl derivatives from acid hydrazides and CS2

An efficient and one-pot method for synthesis of 2-alkylthio-1,3,4- oxadiazole derivatives in mild conditions is described. Some novel derivatives such as bis-1,3,4-oxadiazole analogs are also synthesized.

Synthesis, antibacterial activities, and 3d-qsar of sulfone derivatives containing 1, 3, 4-oxadiazole moiety

A series of sulfone derivatives containing 1, 3, 4-oxadiazole moiety were prepared and evaluated for their antibacterial activities by the turbidimeter test. Most compounds inhibited growth of Ralstonia solanacearum (R. solanacearum) from tomato and tobacco bacterial wilt with high potency, among which compounds 5a and 5b exhibited the most potent inhibition against R. solanacearum from tomato and tobacco bacterial wilts with EC50 values of 19.77 and 8.29 μg/mL, respectively. Our results also demonstrated that 5a, 5b, and a number of other compounds were more potent than commercial bactericides Kocide 3000 and Thiodiazole Copper, which inhibited R. solanacearum from tomato bacterial wilt with EC50 values of 93.59 and 99.80 μg/mL and tobacco bacterial wilt with EC50 values of 45.91 and 216.70 μg/mL, respectively. The structure-activity relationship (SAR) of compounds was studied using three-dimensional quantitative structure-activity relationship (3D-QSAR) models created by comparative molecular field analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA) based on compound bioactivities against tomato and tobacco bacterial wilts. The 3D-QSAR models effectively predicted the correlation between inhibitory activity and steric-electrostatic properties of compounds.

A new route to synthesis of 3,6-diaryl-1,2,4-triazolo[3,4-b]1,3,4- oxadiazoles

Five new 3,6-diaryl-1,2,4-triazolo[3,4-b]1,3,4-oxadiazole derivatives were synthesized by 9 steps from aromatic acids and evaluated for their activities of anticancer and antibacteria. The structures of all new compounds synthesized were elucidated by MS,

Fungicidal agents based on heterocyclically substituted sulphones

Use of compounds of the formula (I) STR1 in which Ar, R and X have the meaning indicated in the description, for combating phytopathogenic fungi in agriculture. The compounds of the formula (I), are known and can be prepared by analogous processes, for ex