237763-52-9

Usage

Chemical classification

Alkyl halide

Physical state

Colorless liquid

Odor

Slightly sweet

Primary use

Chemical intermediate in the synthesis of pharmaceuticals and agrochemicals

Additional use

Reagent in organic chemical reactions, particularly in the formation of carbon-carbon bonds

Flammability

Flammable

Health hazards

Harmful if ingested or inhaled

Safety concerns

Prolonged exposure can cause irritation to the skin, eyes, and respiratory system

Safety protocols

Proper handling and safety measures should be followed to minimize risks during use and storage

Upstream product

• 109-06-8 α-picoline 
• 109-70-6 1.3-chlorobromopropane 
• 17945-79-8 4-(alpha-Pyridyl)butanol 

Relevant academic research and scientific papers

Synthesis of hemilabile P,N ligands: ω-2-pyridyl-n-alkylphosphines

A series of P,N ligands of the general formula (2-py)-(CH2)n-PR2 (2-py: 2-pyridyl; R: i-Pr (n = 1, 4-7), Ph (n = 5-7)) 4a g and 6a has been synthesized. Starting from 2-picoline (1), 2-(ω-chloroalkyl)pyridines 3a-d are prepared. The reactions of 3a-d with (i-Pr)2PLi and Ph2PLi, respectively, result in the title compounds 4a-g in up to 89percent yield. Reaction of Cl-(CH2)3-P(i-Pr)2 with 2-picolyllithium (2) is an alternative route to 4a. Additionally, P,P,N ligands 7a and 9 are synthesized by similar methods. All new compounds were fully characterized. The formation of cyclic pyridinium derivatives 5a and 5b from intramolecular SN reactions of 3a and 3b is discussed in detail.

Photocyclization reactions of cyclohexa- and cyclopenta-fused pyridinium salts. Factors governing regioselectivity

The results of studies described in this report show that irradiation of 1,2-cyclopenta-fused pyridinium perchlorate in aqueous base promotes a remarkably regioselective photocyclization reaction that results in exclusive formation of a single tricyclic a