2392-65-6

Upstream product

• 33305-75-8 L-proline ethyl ester monohydrochloride 
• 147-85-3 L-proline 
• 89311-11-5 N-benzoyl S-proline ethyl ester 
• 98-88-4 benzoyl chloride 
• 5874-58-8 N-(benzoyl)-L-proline 
• 89311-23-9 (S)-ethyl 1-(phenylcarbonothioyl)pyrrolidine-2-carboxylate 

Downstream Products

• 60026-93-9 dimethyl 2,3-dihydro-5-phenyl-1H-pyrrolizine-6,7-dicarboxylate 
• 134926-98-0 ethyl 2-diazo-3-oxo-3-(1-thiobenzoylpyrrolidin-2-yl)propionate 

Relevant academic research and scientific papers

Dakin-west reaction of n-thioacylprolines using trifluoroacetic anhydride: Novel access to 5-trifluoromethylthiazoles

The reaction between N-thioacylprolines and trifluoroacetic anhydride in the presence of pyridine afforded a good yield of 5-trifluoromethylthiazoles. This reaction proceeded through mesoionic 1,3-thiazolium-5-olates, followed by cleavage of the pyrrolidine ring and the formation of thiazoles, introducing a trifluoromethyl group at position 5 in the thiazole ring.

RHODIUM(II) CATALYZED CYCLIZATION OF DIAZO THIOCARBONYL COMPOUNDS FOR HETEROCYCLIC SYNTHESIS

The mesoionic thioisomuenchnone system was prepared from the rhodium(II) acetate catalyzed cyclization of a diazothioamide and was found to undergo smooth 1,3-dipolar cycloaddition with N-phenylmaleimide.In contrast to this system, the rhodium(II) reaction of α-diazo-β-oxo ester containing a thiocarbonyl group produced a cyclic thiocarbonyl ylide which extruded sulfur from a transient episulfide intermediate.