23994-93-6Relevant academic research and scientific papers
Synthesis, dihydrofolate reductase inhibition, anti-proliferative testing, and saturation transfer difference1H-NMR study of some new 2-substituted-4,6-diaminopyrimidine derivatives
Mohebbi, Shohreh,Falcon-Perez, Juan Manuel,Gonzalez, Esperanza,Millet, Oscar,Mato, Jose Maria,Kobarfard, Farzad
experimental part, p. 70 - 78 (2012/03/11)
A series of 2-substituted-4,6-diaminipyrimidine derivatives were synthesized and evaluated for their dihydrofolate reductase (DHFR) inhibitory activity. Saturation transfer difference (STD) 1H-NMR experiments were used to probe the binding char
