24017-91-2Relevant academic research and scientific papers
Cobalt-Catalyzed Aerobic Oxidative C-H/C-H Cross-Coupling of Unactivated Arenes for the Synthesis of Biaryls
Lv, Ningning,Chen, Zhengkai,Liu, Yue,Liu, Zhanxiang,Zhang, Yuhong
, p. 5845 - 5848 (2018)
A mild and efficient protocol for the synthesis of 2,2′-difunctional biaryls from readily available benzamides and oximes by Co(OAc)2·4H2O catalysis has been developed. The catalytic cycle that includes aerobic oxidation of Co(I) to Co(III) is successfully achieved for the first time through dual-chelation-assisted C-H/C-H coupling with the assistance of catalytic Mn(acac)3. The catalytic system exhibits powerful reactivity and tolerates a large number of sensitive functional groups.
Asymmetric Reductive Amination/Ring-Closing Cascade: Direct Synthesis of Enantioenriched Biaryl-Bridged NH Lactams
Zhang, Yao,Liu, Yun-Qi,Hu, Le'An,Zhang, Xumu,Yin, Qin
supporting information, p. 6479 - 6483 (2020/09/02)
We report here a Ru-catalyzed enantioselective synthesis of biaryl-bridged NH lactams through asymmetric reductive amination and a spontaneous ring-closing cascade from keto esters and NH4OAc with H2 as reductant. The reaction features broad substrate generality and high enantioselectivities (up to >99percent ee). To showcase the practical utility, a highly enantioselective synthesis of 5-ethylindolobenzazepinone C, a promising antimitotic agent, has been rapidly completed. Furthermore, the amide group in the products enables versatile elaborations through directed C-H functionalization.
IRIDIUM COMPLEX COMPOUND, COMPOSITION CONTAINING THE COMPOUND AND SOLVENT, AND ORGANIC ELECTROLUMINESCENT ELEMENT, DISPLAY DEVICE AND ILLUMINATION DEVICE CONTAINING THE COMPOUND
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Paragraph 0186; 0190; 0194, (2019/08/30)
PROBLEM TO BE SOLVED: To provide an iridium complex compound in which the light-emission wavelength of light emitting material is made longer. SOLUTION: The present invention provides an iridium complex compound represented by the formula (1) [Ir is an ir
Palladium-Catalyzed β-C?H Arylation of Ketones Using Amino Amide as a Transient Directing Group: Applications to Synthesis of Phenanthridinone Alkaloids
Wang, Junliang,Dong, Cong,Wu, Liangfei,Xu, Mingkai,Lin, Jun,Wei, Kun
supporting information, p. 3709 - 3715 (2018/09/14)
The direct arylation of aromatic and aliphatic ketones was carried out via palladium-catalyzed inert C?H bond functionalization with 2-amino-N-isopropyl-acetamide as a new catalytic transient directing group. The reaction showed excellent functional group compatibility and site selectivity. We demonstrated that α-amino amide forming N,N-bidentate coordination with Pd catalyst is more favorable for the β-arylation of ketones than α-amino acid forming N,O-bidentate coordination with Pd catalyst under relatively mild conditions. This elegant approach provides straightforward access to important structural motifs in organic and medicinal chemistry and is demonstrated here in the efficient synthesis of phenanthridinone alkaloids. (Figure presented.).
Copper-Catalyzed Formation of α-Alkoxycycloalkenones from N-Tosylhydrazones
Su, Naijing,Theorell, Juliana A.,Wink, Donald J.,Driver, Tom G.
supporting information, p. 12942 - 12946 (2015/11/02)
The combination of 20 mol % of copper iodide and lithium tert-butoxide triggers the formation of a broad range of substituted, functionalized α-alkoxy 2H-naphthalenones from readily available N-tosylhydrazones. The data suggests that this transformation occurs through cycloaddition of a copper carbenoid with an ester, followed by a Lewis acid-catalyzed [1,2] alkyl shift of the in situ generated alkoxyepoxide intermediate. The combination of 20 mol % of copper iodide and lithium tert-butoxide triggers the formation of a broad range of substituted, functionalized α-alkoxy 2H-naphthalenones from readily available N-tosylhydrazones. The reaction proceeds by the cycloaddition of a copper carbenoid with an ester, and a subsequent Lewis acid-catalyzed [1,2] alkyl shift of the in situ generated alkoxyepoxide intermediate.
