24021-93-0

Basic information

• Product Name: (1,2-dimethyl-1H-imidazol-5-yl)methanol
• CAS NO: 24021-93-0
• Molecular Formula: C₆H₁₀N₂O
• Molecular Weight: 126.1564
• Mol File: 24021-93-0.mol

Chemical Properties

• Boiling Point: 312°C at 760 mmHg
• Flash Point: 142.5°C
• Density: 1.13g/cm³
• Vapor Pressure: 0.000233mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: (1,2-dimethyl-1H-imidazol-5-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1,2-dimethyl-1H-imidazol-5-yl)methanol(24021-93-0)
• EPA Substance Registry System: (1,2-dimethyl-1H-imidazol-5-yl)methanol(24021-93-0)

Safety Data

• Hazardous Substances Data: 24021-93-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(1,2-dimethyl-1H-imidazol-5-yl)methanol is used as an intermediate for the synthesis of pharmaceutical compounds, due to its high reactivity and ability to act as a ligand or catalyst in various chemical reactions.
Used in Agrochemical Industry:
(1,2-dimethyl-1H-imidazol-5-yl)methanol is used as an intermediate for the synthesis of agrochemicals, contributing to the development of effective and efficient products for agricultural applications.
Used in Dye and Pigment Production:
(1,2-dimethyl-1H-imidazol-5-yl)methanol is used in the production of dyes and pigments, enabling the creation of a wide range of colors and shades for various industries.
Used in Specialty Chemicals:
(1,2-dimethyl-1H-imidazol-5-yl)methanol is used in the production of specialty chemicals, serving as an important building block in organic synthesis and contributing to the development of innovative and high-quality products in the chemical industry.

Upstream product

• 24134-12-1 1,2-dimethyl-1H-imidazole-5-carbaldehyde 
• 1739-84-0 1,2-dimethyl-1H-imidazole 
• 50-00-0 formaldehyd 

Downstream Products

• 24134-09-6 5-bromo-1,2-dimethyl-1H-imidazole 
• 16954-05-5 4,5-dibromo-2-methyl-1-methylimidazole 
• 24134-12-1 1,2-dimethyl-1H-imidazole-5-carbaldehyde 

Relevant articles and documents

PROTEIN KINASE INHIBITORS

The present invention relates to a novel family of inhibitors of protein kinases. In particular, the present invention relates to inhibitors of the members of the Tec and Src protein kinase families.

PROTEIN KINASE INHIBITORS

The present invention relates to a novel family of inhibitors of protein kinases. In particular, the present invention relates to inhibitors of the members of the Tec and Src protein kinase families.

METHYL SULFANYL PYRMIDMES USEFUL AS ANTIINFLAMMATORIES, ANALGESICS, AND ANTIEPILEPTICS

The present invention relates to pyrimidine derivatives of Formula (Ia) and (Ib) (including tautomers, isomers, prodrugs, and pharmaceutically acceptable salts thereof). Said compounds are useful in the treatment of pain (such as neuropathic pain), inflammation, and epilepsy (by acting as anticonvulsants). Methods of medical treatment making use of said compounds, as well as additional compounds of Formula (IIa) and (IIb), are also disclosed.

Development of an efficient process towards the benzimidazole BYK308944: A key intermediate in the synthesis of a potassium-competitive acid blocker

An entirely new synthesis of the important benzimidazole building block BYK308944 was elaborated using the Stobbe reaction as central element. BYK308944 constitutes an important intermediate for the preparation of 3,6,7,8-tetrahydrochromeno[7,8-d] imidazoles as potassium-competitive acid blockers. The new route relies on the hydroxymethylation of 1,2- dimethylimidazole as cheap starting material followed by oxidation of the corresponding alcohol and Stobbe condensation of the resulting aldehyde with diethyl succinate. All synthetic steps of this new approach were optimized particularly with the goal to establish a process amenable for large- scale preparation.

Reactions of 1,2-Dimethylimidazole, Particularly its Metallation

A re-examination of the metallation of 1,2-dimethylimidazole has shown that, after quenching of reaction mixtures with suitable reagents, single products may arise from substitution either in the 2-methyl group or in the 5-position or mixtures of both products may arise, depending on the metallating reagent, solvent, and reaction conditions. 1,2-Dimethylimidazol-5-yl-lithium was prepared by reaction of 1,2-dimethyl-5-trimethylstannylimidazole (13) with n-butyl-lithium in tetrahydrofuran at -100 deg C.The corresponding 5-trimethylsilyl compounds (12) was metallated by n-butyl-lithium exclusively in the 2-methyl group. 1,2-Dimethylimidazol-5-yl-lithium was shown to undergo transmetallation reactions at temperatures higher than -100 deg C.An improved procedure is given for the synthesis of 1,2-dimethylimidazole-5-carbaldehyde via hydroxymethylation of 1,2-dimethylimidazole and oxidation of the 5-hydroxymethyl group with nitric acid.