24030-10-2

Upstream product

• 20442-65-3 1-(4-methylphenyl)-3-phenylprop-2-yn-1-one 
• 57-13-6 urea 
• 4224-96-8 3-phenyl-1-p-tolylprop-2-en-1-one 
• 100-52-7 benzaldehyde 
• 122-00-9 para-methylacetophenone 
• 585-71-7 (1-bromoethyl)benzne 
• 104-81-4 4-Methylbenzyl bromide 
• 104-87-0 4-methyl-benzaldehyde 
• 98-86-2 acetophenone 
• 49593-56-8 4-phenyl-6-p-tolyl-3,4-dihydro-1H-pyrimidin-2-one 

Relevant academic research and scientific papers

Synthesis of 4,6-diarylpyrimidin-2(1H)-one derivatives from benzyl halides and (1-bromoethyl)benzene under solvent-free conditions

A facile synthesis of a series of pyrimidinone derivatives from the reaction of benzyl halides, (1-bromoethyl)benzene and urea in the presence of pyridine N-oxide (PNO) under solvent-free conditions is described. This transformation presumeably occurs via oxidation/cross-aldol condensation/Michael addition/intra molecular cyclization, domino sequence, involving the formation of one C–C bond and two C–N bonds in a single step.

Highly effectual synthesis of 4,6-diarylpyrimidin-2(1H)-ones using N,N,N′,N′-Tetramethylethylenediaminium-N,N′-disulfonic acid hydrogen sulfate as a dual-functional catalyst

The highly effectual synthesis of 4,6-diarylpyrimidin-2(1H)-ones via the one-pot multicomponent reaction of acetophenones with arylaldehydes and urea in the presence of trimethylsilyl chloride and a catalytic amount of the ionic liquid N,N,N′,N′-Tetrameth

Method for catalytically synthesizing 4,6-diaryl pyrimidine-2(1H)-one derivative by using sulfonic acid functional chitosan

The invention belongs to the technical field of green organic chemistry, and particularly relates to a method for catalytically synthesizing a pyrimidones derivative by using natural polymer modified sulfonic acid functional chitosan. The method comprises

Br?nsted acidic ionic liquids catalyzed three-component synthesis of 4,6-diarylpyrimidin-2(1H)-ones under solvent-free conditions

4,6-Diarylpyrimidin-2(1H)-one derivatives have been synthesized from three-component reaction of aromatic aldehyde derivatives, acetophenone, and urea (thiourea) in the presence of Br?nsted acidic ionic liquids such as triethylammonium hydrogensulfate, N-

A one-pot three-component synthesis of 4,6-diarylpyrimidin-2(1H)-ones (DAPMs) using atomized sodium in THF under sonic condition

A simple and an efficient procedure for the synthesis of 4,6-diarylpyrimidin-2(1H)-ones using atomized sodium/THF via a one-pot three-component Biginelli-like cyclocondensation of an aldehyde, a methyl ketone and urea under ultrasonic condition is develop

4,6-Diaryl/heteroarylpyrimidin-2(1H)-ones as a new class of xanthine oxidase inhibitors

Summary A series of 4,6-diaryl/heteroarylpyrimidones was synthesized employing silica-supported fluoroboric acid under solvent-free conditions in a microwave reactor. The catalytic influence of HBF4-SiO2 was investigated in detail to

Synthesis of diarylpyrimidinones (DAPMs) using large pore zeolites

A series of diarylpyrymidin-2(1H)-one (DAPM) belongs to one of the important class of therapeutic and pharmacological active hetrocycles, were synthesized through the multicomponent reactions (MCRs) of aldehydes, ketone and urea, followed by the heterogen

Iodine-catalyzed versatile synthesis of 4,6-diarylpyrimidin-2(1H)-ones (DAPMs) via one-pot, multicomponent reaction

An efficient, solvent-free, one-pot, three-component cyclocondensation reaction between aldehyde, ketone, and urea to give 4,6-diarylpyrimidin-2(1H)- ones (DAPMs) using iodine as catalyst is described. This new protocol provides a simple and environmental

Biginelli-like cyclocondensation reaction: Efficient synthesis of 4,6-diarylpyrimidin-2(1H)-one under solvent-free conditions

An efficient and facile synthesis of 4,6-diarylpyrimidin-2(1H)-one via a Biginelli-like reaction of aromatic aldehydes, aromatic ketones, and urea in the presence of NaOH under solvent-free conditions using a heating method has been developed. Compared wi

H3PMo12O40 catalyzed three-component one-pot synthesis of 4,6-diarylpyrimidin-2(1H)-ones under solvent-free conditions

4,6-Diarylpyrimidin-2(1H)-one derivatives have been synthesized from three-component one-pot condensation of acetophenone derivatives, aldehydes and urea in the presence of trimethylsilyl chloride and a catalytic amount of H3PMo12Os