24051-35-2

Basic information

• Product Name: 1-(3-Chlorophenyl)pyrrolidin-2-one
• Synonyms: 1-(3-Chlorophenyl)pyrrolidin-2-one
• CAS NO: 24051-35-2
• Molecular Formula: C₁₀H₁₀ClNO
• Molecular Weight: 195.6455
• Mol File: 24051-35-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 66 °C
• Boiling Point: 143 °C(Press: 0.7 Torr)
• Appearance: /
• Density: 1.283±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -0.61±0.20(Predicted)
• CAS DataBase Reference: 1-(3-Chlorophenyl)pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-Chlorophenyl)pyrrolidin-2-one(24051-35-2)
• EPA Substance Registry System: 1-(3-Chlorophenyl)pyrrolidin-2-one(24051-35-2)

Safety Data

• Hazardous Substances Data: 24051-35-2(Hazardous Substances Data)

Usage

General Description

1-(3-Chlorophenyl)pyrrolidin-2-one, also known as 3'-chloro-α-pyrrolidinopropiophenone, is a chemical compound that belongs to the class of pyrrolidinones. It is a psychoactive substance and is widely used as a recreational drug, often sold under the street name "3'-chloro-α-pvp" or "3-Cl-PVP." 1-(3-Chlorophenyl)pyrrolidin-2-one is a stimulant and is known to produce effects similar to other cathinones, such as increased alertness, euphoria, and increased energy. It is often found in the form of white powder and is typically ingested, snorted, or injected. However, the use of 1-(3-Chlorophenyl)pyrrolidin-2-one has been associated with a range of negative health effects, including addiction, cardiovascular issues, and mental health problems. Due to its potential for abuse and harm, it is considered a controlled substance in many countries.

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Relevant articles and documents

Aluminium Chloride-Mediated Synthesis of 1-Chloro-2,2,2-Trifluoroethylidene-Substituted Pyrrolidones

An aluminium chloride-mediated cascade reaction between pyrrolidones and trifluoroacetic anhydride is reported. Functionally diverse 1-chloro-2,2,2-trifluoroethylidene-substituted pyrrolidones were obtained in moderate to high yields through electrophilic trifluoroacetylation, nucleophilic chlorination, and elimination. This procedure has a wide scope, good functional-group tolerance and the reaction conditions are amenable to scale up. Additionally the obtained 1-chloro-2,2,2-trifluoroethylidene products can be applied to further functionalization as trifluoromethyl-containing building blocks. Some of the title compounds showed fungicidal activity against cucumber downy mildew (CDM). (Figure presented.).

Efficient ligand-free copper-catalyzed N-arylation of amides with aryl halides in water

A convenient and efficient protocol has been developed for the cross-coupling of amides and aryl iodides using a ligand-free copper(I) oxide catalyst in water. A variety of amide derivatives afforded the corresponding N-arylated products in moderate to good yields (up to 88%).