24118-70-5

Upstream product

• 15761-50-9 (R)-4-amino-2-methylpentane 
• 104-15-4 toluene-4-sulfonic acid 
• 98-59-9 p-toluenesulfonyl chloride 
• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 
• 61-90-5 L-leucine 
• 2666-93-5 (S)-Leu-OMe 
• 28659-91-8 (R)-2-Isobutyl-aziridine 
• 182949-58-2 C₁₃H₁₉NO₂S 
• 70-55-3 toluene-4-sulfonamide 
• 108-10-1 4-methyl-2-pentanone 
• 15761-50-9 2-amino-4-methylpentane 

Downstream Products

• 101833-46-9 (S)-N-((R)-1,3-Dimethyl-butyl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide 
• 20445-29-8 N-((R)-1,3-Dimethyl-butyl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide 

Relevant academic research and scientific papers

Asymmetric Stepwise Reductive Amination of Sulfonamides, Sulfamates, and a Phosphinamide by Nickel Catalysis

Asymmetric reductive amination of poorly nucleophilic sulfonamides was realized in the presence of nickel catalysts and titanium alkoxide. A wide range of ketones, including enolizable ketones and some biaryl ones, were converted into sulfonamides in excellent enantiomeric excess. The cyclization of sulfamates and intermolecular reductive amination of a diarylphosphinamide were also successful. Formic acid was used as a safe and economic surrogate of high-pressure hydrogen gas.

SYNTHESIS OF THE RACEMIC FORM OF (Z)-1,17-DIAMINOOCTADEC-9-ENE, AN ALIPHATIC DIAMINE FROM COCCINELLIDAE. DETERMINATION OF THE ABSOLUTE CONFIGURATION OF THE (+)-NATURALLY-OCCURRING ANTIPODE

The total synthesis of the title compound (1) has been achieved.Also reported is the use of lanthanide induced shifts in 1H NMR spectroscopy to assign the absolute configuration of the α-carbon atom in chiral primary α-methylalkylamines.Application of this empirical method to natural (+)-1 shows that it has the R-configuration at C-17.