24126-98-5

Basic information

• Product Name: 1-(2,4-Dihydroxyphenyl)-2-(3,4-dimethoxyphenyl)ethanone
• Synonyms: 1-(2,4-Dihydroxyphenyl)-2-(3,4-dimethoxyphenyl)ethanone;1-(2,4-dihydroxyphenyl)-2-(3,4-dimethoxyphenyl)ethan-1-one
• CAS NO: 24126-98-5
• Molecular Formula: C₁₆H₁₆O₅
• Molecular Weight: 288.3
• Mol File: 24126-98-5.mol
• Article Data: 15

Chemical Properties

• Melting Point: 180 °C
• Boiling Point: 483.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.272±0.06 g/cm3(Predicted)
• PKA: 7.62±0.35(Predicted)
• CAS DataBase Reference: 1-(2,4-Dihydroxyphenyl)-2-(3,4-dimethoxyphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4-Dihydroxyphenyl)-2-(3,4-dimethoxyphenyl)ethanone(24126-98-5)
• EPA Substance Registry System: 1-(2,4-Dihydroxyphenyl)-2-(3,4-dimethoxyphenyl)ethanone(24126-98-5)

Safety Data

• Hazardous Substances Data: 24126-98-5(Hazardous Substances Data)

Usage

Preparation

Preparation by Friedel–Crafts acylation of resorcinol with 3,4-dimethoxyphenylacetyl chloride in nitro- benzene in the presence of aluminium chloride for 24 h at r.t. (56%).

Upstream product

• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 108-46-3 recorcinol 
• 93-17-4 3,4-dimethoxyphenylacetonitrile 

Downstream Products

• 53084-05-2 2-(3,4-dimethoxyphenyl)-1-(2-hydroxy-4-methoxyphenyl)-ethanone 
• 342643-56-5 3-(3,4-dimethoxy-phenyl)-7-methoxymethoxy-chroman-4-one 
• 857555-86-3 {2-[(3,4-dimethoxy-phenyl)-acetyl]-5-methoxy-phenoxy}-acetic acid 
• 111329-58-9 6-methoxy-3-veratryl-benzofuran-2-carboxylic acid 
• 1173910-47-8 7-hydroxy-3',4'-dimethoxyisoflavane 
• 24160-14-3 cladrin 
• 54528-39-1 3-(3,4-dimethoxyphenyl)-7-hydroxy-2-methyl-4H-chromen-4-one 

Relevant articles and documents

Development of a novel truncated deguelin derivative possessing nitric oxide donor as a potential anti-lung cancer agent

Lung cancer is the leading cause of cancer death in the world. Natural product deguelin and its truncated analogs have been reported to be potential therapeutic agents for lung cancer. In order to improve the potency, a novel truncated deguelin derivative

Enantioselective Synthesis of Isoflavanones and Pterocarpans through a RuII-Catalyzed ATH-DKR of Isoflavones

Noyori-Ikariya RuII complexes promoted the one-pot C=C/C=O bonds reduction of isoflavones using sodium formate as the hydrogen source through Asymmetric Transfer Hydrogenation-Dynamic Kinetic Resolution (ATH-DKR). Due to the neutral conditions employed, isoflavones with different substituents at the 2’-position of B-ring (H, OH, OMe and Br) were successfully reduced. Ten cis-3-phenylchroman-4-ols were selectively obtained (>20 : 1 dr) in good yields (up to 86 %) and excellent enantioselectivities (up to >99 : 1 er). The synthetic applications of these chiral compounds were also demonstrated. Enantioenriched isoflavanones were obtained under mild metal-free oxidation of the cis-3-phenylchroman-4-ols while pterocarpans were synthesized by two strategies: an acid-catalyzed cyclization and a novel approach based on a Pd-catalyzed C?O intramolecular cross-coupling reaction.

A Concise Approach to Oxo-Dehydrorotenoid by Direct Lactonization and the Total Syntheses of Stemonone, Rotenonone, 6-Oxo-dehydroelliptone, and 6-Oxo-6a,12a-dehydrodeguelin

An approach to construct the oxo-dehydrorotenoids via direct lactonization of isoflavone-2-carboxylic acids is reported. The present reaction proceeds smoothly with good substrate scope and an operationally simple protocol. The application of this method