2419-73-0Relevant articles and documents
Intermediate compound for synthesizing dithioerythritol, application of intermediate compound and synthesis method of dithioerythritol
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Paragraph 0052-0053, (2020/05/14)
The invention discloses an intermediate compound for synthesizing dithioerythritol, an application of the intermediate compound and a synthesis method of the dithioerythritol. The intermediate compound is 2, 3-diacetyl thiomethylethylene oxide, and the chemical formula of the intermediate compound is shown in the specification, and the intermediate compound can be prepared by performing substitution reaction on 2, 3-dibromomethylethylene oxide and thioacetate. The synthesis method of the dithioerythritol comprises the step of carrying out hydrolysis reaction on the intermediate compound. The 2, 3-diacetyl thiomethylethylene oxide can be directly hydrolyzed to obtain the dithioerythritol, the preparation of the 2, 3-diacetyl thiomethyl ethylene oxide is simple, a new synthesis idea is provided for the synthesis of the dithioerythritol, the synthesis route is short, the operation is simple and convenient, and the yield is high.
X-ray contrast agents
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, (2008/06/13)
Compounds of the general formula: STR1 (where R is a group --CH(CH2 OH)2 or --CH2 CH(OH)CH2 OH and A is a group --CH2 CH(OH)CH2 -- or --CH2 CH(OH)CH(OH)CH2 --) possess a package of favourable parameters which render them of particular use not only in all forms of intravascular visualisation but also in myelography. The compounds are prepared by reaction of an appropriate 5-acetylamino-N,N'-bis(hydroxypropyl)-2,4,6-triiodoisophthalamide with an agent effective to introduce the appropriate hydroxyalkylene group such as for example epichlorohydrin or 1,4-dichloro-2,3-dihydroxybutane.