24190-08-7

Upstream product

• 7472-67-5 α-phenyl-α-methoxypropanoic acid 
• 682351-19-5 ((R)-1,2,2-Trimethoxy-1-methyl-ethyl)-benzene 
• 682351-17-3 (R)-2-hydroxy-2-phenylpropanal dimethyl acetal 
• 526221-22-7 (R)-1,1-Dichloro-2-phenyl-propan-2-ol 
• 121569-35-5 (S)-2-Chloro-2-phenyl-propionaldehyde 
• 98857-41-1 (R)-(+)-1-trimethylsiloxyethylbenzene 
• 1517-69-7 (R)-1-phenylethanol 
• 3558-61-0 methyl 2-methoxy-2-phenylacetate 
• 4358-87-6 (RS)-methyl mandelate 
• 167640-30-4 (αR,α'R,4R,5R)-2,2,α,α'-tetramethyl-α,α'-diphenyl-1,3-dioxolane-4,5-dimethanol 
• 912646-24-3 (4R,5R)-4,5-bis((R)-1-methoxy-1-phenylethyl)-2,2-dimethyl-1,3-dioxolane 
• 912646-25-4 (2R,3R,4R,5R)-2,5-dimethoxy-2,5-diphenylhexane-3,4-diol 
• 91899-79-5 (S)-2-methoxy-2-phenylpropanal 

Downstream Products

• 24190-12-3 (-)-1,1,2-Trimethyl-2-methoxy-2-phenyl-propanol-1 
• 832688-51-4 (R)-5-methoxy-5-phenylhexane-2,4-dione 
• 832688-52-5 (R)-3⁽⁵⁾-(1-methoxy-1-phenyl-ethyl)-5⁽³⁾-methyl-1H-pyrazole 
• 832688-55-8 (R)-2-chloro-6-[3-(1-methoxy-1-phenylethyl)-5-methylpyrazol-1-yl]pyridine 
• 832688-57-0 (R)-2-[3-(1-methoxy-1-phenylethyl)-5-methylpyrazol-1-yl]pyridine-1-oxide 
• 98324-55-1 (1R,3R,4S:R)-(-)-menthyl 2-methoxy-2-phenylpropionate 
• 1033560-03-0 (R)-2-Methoxy-2-phenyl-propionyl chloride 
• 24190-11-2 (R)-2-methoxy-2-phenylpropionic acid methyl ester 

Relevant academic research and scientific papers

A general synthesis of 2-alkoxy-2-phenylpropanoic acids

A preparation of a variety of 2-alkoxy-2-phenylpropanoic acids in two steps is described. Epoxidation of α-methylstyrene with mCPBA in methanol or primary alcohol solvents proceeded with an acid-catalyzed in situ ring opening reaction to give the corresponding 2-alkoxy-2-phenyl-1-propanols in 28-91% yield. Lower yields were realized with secondary (22-58%) and tertiary (14%) alcohols. These alcohols were cleanly oxidized to the corresponding carboxylic acids using a mild Heyns' oxidation (O2, Pt/C) in generally good to excellent yields (25-92%). The derived (S)-α-methylbenzylamide diastereomers are nearly all well separated by capillary GC, and the use of this method to determine the enantiomeric purity of brucine-resolved 2-methoxy-2-phenylpropanoic acid was demonstrated.

Asymmetric synthesis of both enantiomers of α-methyl-α-methoxyphenylacetic acid from l-(+)-tartaric acid: formal enantioselective synthesis of insect pheromone (-)-frontalin

Both antipodes of α-methyl-α-methoxyarylacetic acid derivatives were prepared from a common chiralpool precursor l-(+)-tartaric acid. The key step involves the addition of Grignard reagents to 1,4-diketones derived from tartaric acid. The utility of this

Regioselective synthesis of optically active (pyrazolyl)pyridines with adjacent quaternary carbon stereocenter: Chiral N,N-donating ligands

Novel optically active 2-(pyrazol-1-yl)pyridines have been prepared using resolved the O-methyl ether of atrolactic acid as a source of the adjacent quaternary carbon stereocenter. Different regioisomers were formed selectively in the reaction of 2-hydraz

Stereospecific Construction of Chiral Quaternary α-Oxygenated Aldehydes from Chiral Secondary Alcohol Derivatives

Chiral tertiary dichloromethylcarbinol derivatives 2, prepared from protected chiral secondary alcohols 1, were converted stereospecifically into chiral quaternary α-oxygenated aldehyde derivatives 4 and 11 via intermediary α-chloroepoxides 3 under weakly