242147-78-0

Upstream product

• 3891-07-4 N-(2-Hydroxyethyl)phthalimide 
• 22423-26-3 O-2,2'-cyclo-5-methyluridine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 242147-77-9 2'-O-phthalimidoethyl-5-methyluridine 

Downstream Products

• 1616093-48-1 C₅₀H₅₆N₅O₁₁P 
• 1616093-48-1 C₅₀H₅₆N₅O₁₁P 
• 242147-79-1 2'-O-[2-(amino)ethyl]-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine 
• 242147-80-4 2'-O-[N-(2-cyanoethoxycarbonyl)-2-aminoethyl]-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine 

Relevant academic research and scientific papers

Guanidinium functionalized oligonucleotides and method/synthesis

The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to include a guanidinium group. These oligomers are useful for diagnostic, therapeutic and investigative purposes.

Methods for the preparation of conjugated oligomers

The present invention provides novel methods for preparing oligonucleotide conjugates using a novel electrophilic haloacetyl linker. Novel compounds and intermediates are also disclosed.