24243-40-1Relevant academic research and scientific papers
Method of Synthesis for Mycophenolic Acid and Its Phenylsulfenyl and Phenylseleny Analogues
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, (2020/10/10)
The present invention relates to: a method for synthesizing mycophenolic acid and phenylsulfenyl and phenylselenyl derivatives thereof; and novel phenylsulfenyl and phenylselenyl derivative compounds of mycophenolic acid synthesized by the synthesis method. The novel synthesis method of mycophenolic acid of the present invention does not use a protecting group compared to a conventional synthesis method, has a simple reaction step, and has a high yield. Therefore, the synthesis method of the present invention can usefully use mycophenolic acid in a high-yield mass production method.
A mycophenolic acid homogeneous phase enzyme immune detection reagent and its preparation and detection method
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Paragraph 0070; 0071; 0072, (2017/01/02)
The invention relates to a mycophenolic acid detection reagent as well as preparation and detection methods thereof and particularly relates to a mycophenolic acid homogeneous phase enzyme immunological detection reagent as well as preparation and detection methods thereof. The mycophenolic acid homogeneous phase enzyme immunological detection reagent comprises an anti-mycophenolic acid specific antibody, and an indication reagent for detecting an anti-mycophenolic acid specific antibody-mycophenolic acid compound; and the anti-mycophenolic acid specific antibody is prepared from mycophenolic acid immunogen immunological animals. The mycophenolic acid detection reagent has the beneficial effects that mycophenolic acid immunogen has strong specificity and high immunogenicity; the prepared anti-mycophenolic acid specific antibody has strong specificity and high valence and has no crossed reaction with common 62 types of medicines; the homogeneous phase enzyme immunological detection reagent containing the anti-mycophenolic acid specific antibody can be used for conveniently, rapidly and accurately determining the content of mycophenolic acid in a sample, and determining a plurality of samples on a full-automatic biochemical analyzer at the same time, so that the high-flux rapid determination for the mycophenolic acid is realized; and the accuracy is high, the specificity is strong, and the accuracy and the detection efficiency can be relatively greatly improved.
