24265-34-7

Usage

Synthesis Reference(s)

Tetrahedron, 64, p. 5756, 2008 DOI: 10.1016/j.tet.2008.04.010

InChI:InChI=1/C8H6ClNO4/c9-5-8(11)14-7-4-2-1-3-6(7)10(12)13/h1-4H,5H2

Upstream product

• 79-11-8 chloroacetic acid 
• 88-75-5 2-hydroxynitrobenzene 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 24255-20-7 Trimethylammonio-essigsaeure-o-nitro-phenylesterchlorid 
• 98554-71-3 3,4-dihydro-2H-1,4-benzoxazin-2-one 
• 1383579-88-1 C₈H₈ClNO₂ 
• 1383579-80-3 C₁₆H₁₅FN₂O₄S 
• 95-55-6 2-amino-phenol 
• 10147-68-9 N-(2-hydroxyphenyl)-2-chloroacetamide 

Relevant academic research and scientific papers

Pyruvate kinase activators for use for increasing lifetime of the red blood cells and treating anemia

Described herein are methods for using compounds that activate pyruvate kinase.

BICYCLIC PKM2 ACTIVATORS

Compounds and compositions comprising compounds including formula (I) that activate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that activate PKM2 in the treatment of cancer.

A convenient synthesis of 3,4-dihydro-1,4-benzoxazin-2-ones

3,4-Dihydro-1,4-benzoxazin-2-one was prepared for the first time by catalytic hydrogenation of 4-benzyl-3,4-dihydro-1,4-benzoxazin-2-one. A simple and efficient synthesis of 4-benzyl- and 4-alkyl-3,4-dihydro-1,4-benzoxazin-2-one derivatives from ethyl 2-(2-hydroxyphenylamino)acetate and aldehydes is described. Some considerations regarding the reactivity of 3,4-dihydro-1,4-benzoxazin-2-ones are given.