2427-06-7

Basic information

• Product Name: 1,4-dimethyl-1,2,3,4-tetrahydroquinoxaline
• Synonyms: Quinoxaline, 1,2,3,4-tetrahydro-1,4-dimethyl-
• CAS NO: 2427-06-7
• Molecular Formula: C₁₀H₁₄N₂
• Molecular Weight: 162.2316
• Mol File: 2427-06-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 262.3°C at 760 mmHg
• Flash Point: 106.8°C
• Density: 1.024g/cm³
• Vapor Pressure: 0.011mmHg at 25°C
• Refractive Index: 1.548
• CAS DataBase Reference: 1,4-dimethyl-1,2,3,4-tetrahydroquinoxaline(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-dimethyl-1,2,3,4-tetrahydroquinoxaline(2427-06-7)
• EPA Substance Registry System: 1,4-dimethyl-1,2,3,4-tetrahydroquinoxaline(2427-06-7)

Safety Data

• Hazardous Substances Data: 2427-06-7(Hazardous Substances Data)

Usage

Class

Tetrahydroquinoxaline compounds

Physical state

Colorless liquid

Solubility

Insoluble in water, soluble in organic solvents

Uses

Building blocks in the synthesis of pharmaceuticals and organic molecules

Applications

Synthesis of pharmaceuticals and agrochemicals

Potential

Therapeutic agent for various medical conditions

Safety precautions

Toxic if ingested or inhaled, causes skin and eye irritation upon contact

Handling

Handle with care, use appropriate protective equipment and follow safety guidelines

Upstream product

• 10579-71-2 1,4-diformyl-1,2,3,4-tetrahydroquinoxaline 
• 103441-56-1 N-(3-chloro-phenyl)-N,N'-dimethyl-ethylenediamine 
• 67-56-1 methanol 
• 91-19-0 2,3-diethynylquinoxaline 
• 64-18-6 formic acid 
• 110-70-3 N,N`-dimethylethylenediamine 
• 583-53-9 2,3-dibromobenzene 
• 583-55-1 1-Bromo-2-iodobenzene 
• 615-42-9 1,2-Diiodobenzene 
• 7006-52-2 3-chloro-N-methylaniline 
• 4819-33-4 3-chloro-N-(2-chloro-ethyl)-N-methyl-aniline 
• 3476-89-9 1,2,3,4-tetrahydroquinoxaline 
• 91-16-7 1,2-dimethoxybenzene 
• 139-71-9 m-chloroformanilide 

Relevant articles and documents

Synthesis of Quinoxaline Derivatives via Copper(I)-Catalyzed Cross-Coupling Reaction of 1,2-Dihalobenzenes with N,N′-Disubstituted Ethane-1,2-diamines under Ligand- and Solvent-Free Conditions

An efficient ligand- and solvent-free method for the synthesis of quinoxaline derivatives via copper(I)-catalyzed cross-coupling process has been developed. 1,2-Halobenzenes or 1,8-diiodonaphthalene coupled with N,N′-disubstituted ethane-1,2-diamines to g

Direct Substitution of Aromatic Ethers by Lithium Amides. A New Aromatic Amination Reaction

Reaction of lithiated dialkylamines with methoxy aromatics in refluxing THF leads to products resulting from a direct ipso-substitution.Especially with lithiated secondary amines high conversions and selectivities are achieved.Sulfonyl-substituted aromatics react equally well, but halogenated aromatics give rise to side-products arising from a competing pathway via aryne intermediates.The scope and mechanistic implications of this novel nucleophilic amination reaction are described.