24279-55-8

Upstream product

• 1243153-55-0 N-allyl-5-chloro-3-hydroxy-3-phenylindol-2-amine 
• 17630-76-1 5-chloroindole 2,3-dione 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 100-58-3 phenylmagnesium bromide 
• 10352-28-0 N-(2-benzoyl-4-chlorophenyl)formamide 
• 24284-35-3 5-chloro-3-hydroxy-3-phenyl-3H-indol-2-one 

Downstream Products

• 37647-59-9 8-Chloro-2,3,4,10-tetrahydro-10-phenylpyrimido[1,2-a]indol-10-ol 
• 1243153-75-4 (S)-2-amino-5-chloro-3-hydroxy-3-phenylindole 
• 1243153-76-5 (R)-2-amino-5-chloro-3-phenylindol-3-oI 

Relevant academic research and scientific papers

2-AMINOINDOLE COMPOUNDS AND METHODS FOR THE TREATMENT OF MALARIA

The present invention relates to methods of treating a subject with malaria comprising administering a 2-aminoindole compound represented by Formula: (I)- The values and preferred values of the variables in Structural Formula I are defined herein.

A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity

The development of a concise strategy to access 2-amino-3-hydroxy-indoles, which are disclosed as novel antimalarials with potent in vivo activity, is reported. Starting from isatins the target compounds are synthesized in 2 steps and in good yields via oxoindole intermediates by employing tert- butyldimethylsilyl amine (TBDMSNH2) as previously unexplored ammonia equivalent.