Synthesis and applications of fluorous silyl protecting groups with improved acid stability

DOI: 10.1016/S0040-4039(99)01106-5

Source and publish data:

Tetrahedron Letters p. 5667 - 5670 (1999)

Update date:2022-08-03

Topics:

Authors:

Roever, Stephan

Wipf, Peter

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Article abstract of DOI:10.1016/S0040-4039(99)01106-5

Fluorous alkoxysilyl protecting groups have been developed and evaluated for their acid stability. tert-Butylphenyl-1H,1H,2H,2H-heptadecafluorodecyloxysilyl (BPFOS) ethers in particular were found to be surprisingly acid stable and allow simple protection-purification-deprotection schemes by liquid-liquid extraction with FC-72/CH₃CN or by solid phase extraction with fluorous reverse phase silica gel.

Full text of DOI:10.1016/S0040-4039(99)01106-5

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Product name:tert-butyl-phenyl-1H,1H,2H,2H-heptadecafluorodecyloxysilyl bromide

Cas No:243645-01-4

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Jinan Hongfangde Pharmatech Co.,Ltd

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Shijiazhuang Haotian Chemical Co., Ltd.

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Zhuhai Rundu Pharmaceutical co.,Ltd

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Hangzhou Taiyan Trading Co., Ltd(expird)

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