244-50-8Relevant academic research and scientific papers
α,α-disubstituted aromatics and heteroaromatics as cognition enhancers
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, (2008/06/13)
Cognitive defeciencies or neurological dysfunction in mammals are treated with α,α-disubstituted aromatic or heteroaromatic compounds. The compounds have the formula: STR1 or a salt thereof wherein X and Y are taken together to form a saturated or unsaturated carbocyclic or heterocyclic first ring and the shown carbon in said ring is α to at least one additional aromatic ring or heteroaromatic ring fused to the first ring; one of Het1 is 2, 3 or 4-pyridyl or 2, 4, or 5-pyrimidinyl and the other is selected from (a) 2, 3, or 4-pyridyl, (b) 2, 4, or 5-pyrimidinyl, (c) 2-pyrazinyl, (d) 3, or 4-pyridazinyl, (e) 3, or 4-pyrazolyl, (f) 2, or 3-tetrahydrofuranyl, and (g) 3-thienyl.
An Investigation of 1,8-Diazafluorenylidene. A Carbene with Unusual Properties
Li, Yu-Zhuo,Schuster, Gary B.
, p. 3804 - 3811 (2007/10/02)
Irradiation of 9-diazo-1,8-diazafluorene initiates a series of photochemical reactions that lead to isomerization to the diazirine and to loss of nitrogen to form a carbene.The carbene has a triplet ground state but reacts primarily from its upper singlet state.The chemical and physical properties of the diazo compound and the carbene are compared with those for 9-diazofluorene.The differences between these compounds are assigned tentatively to a combination of through-space interaction of the lone pair electrons of the heteroatomic ring atoms with the nonbonding in-plane orbital of the carbene carbon and the electron-withdrawing nature of the pyridine-like nitrogens.
REACTIONS OF AZAFLUORENONES WITH HYDRAZINE
Mlochowski, Jacek,Szulc, Zdzislaw
, p. 33 - 39 (2007/10/02)
Formation and transformations of hydrazones, phenylhydrazones and azines, azafluorenone derivatives, have been studied and the influence of positions of heterocyclic nitrogen atoms on the reduction mechanism discussed.An improved reduction method of azafluorenones to azafluorenes has been elaborated.
