2441-41-0Relevant articles and documents
HUMAN MICROBIOTA DERIVED N-ACYL AMIDES FOR THE TREATMENT OF HUMAN DISEASE
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Page/Page column 87-88, (2019/01/17)
The present invention provides compositions and methods for the modulation of G protein-coupled receptors (GPCRs). The invention provides a genetically engineered cell, wherein the cell expresses a human microbial N-acyl synthase (hm-NAS) gene. In one embodiment, the hm-NAS gene is N-acyl serinol synthase. The invention provides a probiotic composition, the probiotic composition comprises a genetically engineered cell of the invention. The invention provides a method for modulating a G protein-coupled receptor (GPCR) activity in a subject, the method comprises administering to the subject an effective amount of a composition comprising at least one selected from the group consisting of a genetically engineered cell, an hm-NAS gene, and a N-acyl amide.
Long-acting entecavir prodrug and preparation method and application thereof
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Paragraph 0081; 0082; 0084, (2019/04/17)
The invention relates to a long-acting entecavir prodrug and a preparation method and application thereof. The long-acting entecavir prodrug has a structure shown as formula I that is shown in the description; the long-acting entecavir prodrug can release slowly, continuously and stably in vivo and convert into an entecavir material technical, so that long acting is achieved. In the formula I, R1,R2 and R3 are defined the same as in the description.
Lipid dipeptide and gel
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Page/Page column 23-24, (2016/05/19)
A gelator that includes a lipid peptide of Formula (1) wherein R1 is a C9-23 aliphatic group, R2 is a hydrogen atom or a C1-4 alkyl group optionally having a C1-2 branched chain, R3 is a —(CH2)n—X group, n is a number from 1 to 4, and X is an amino group, a guanidino group, a —CONH2 group, or a 5-membered ring optionally having 1 to 3 nitrogen atoms, a 6-membered ring optionally having 1 to 3 nitrogen atoms, or a fused heterocycle including a 5-membered ring and a 6-membered ring that optionally has 1 to 3 nitrogen atoms; or a pharmaceutically usable salt of the lipid peptide.