24424-11-1Relevant academic research and scientific papers
Bicyclization involving pseudo-intramolecular imination with diamines
Nishiwaki, Nagatoshi,Hirao, Shotaro,Sawayama, Jun,Saigo, Kazuhiko,Kobiro, Kazuya
, p. 4938 - 4940 (2011)
α-Nitro-δ-keto nitriles and α-nitro-δ-keto ester were readily converted to diazabicyclo compounds having vicinal functionality upon treatment with diamines. The keto nitrile attracts the diamine nearby to an acidic hydrogen to cause the pseudo-intramolecu
2,3,5 TRISUBSTITUTED PYRROLE DERIVATIVES AS TOPOISOMERASE INHIBITORS AND THERAPEUTIC USES THEREOF
-
, (2017/03/14)
The compounds of Formula (1) having topoisomerase inhibitory effect includes [Formula should be inserted here] wherein, R1 is selected from a group consisting of H, OR5, optionally substituted C1-C12 alkyl, haloalkyl, C2-C12alkenyl, C2-C12alkynyl, C1-C12alkyloxy, C1-C12haloalkyloxy, C2-C10 heteroalkyl, C3- C12 cycloalkyl, C3-C12cycloalkenyl, C2- C12heterocycloalkyl, C2-C2 heterocycloalkenyl, C6-C18aryl, and C1-C18heteroaryl; R2, R3 and R4 are independently selected from a group consisting of H, halogen, CN, - NO2, SH, CF3, OH, CO2H, CONH2, OCF3, optionally substituted C1-C12alkyl, optionally substituted C1-C12haloalkyl optionally substituted C2-C12alkenyl, optionally substituted C2- C12alkynyl, optionally substituted C1-C12alkyloxy, optionally substituted C1- C12haloalkyloxy, optionally substituted C2-C12heteroalkyl, optionally substituted C3- C12cycloalkyl, optionally substituted C3-C12 cycloalkenyl, optionally substituted C2-C12 heterocycloalkyl, optionally substituted C2-C12 heterocycloalkenyl, optionally substituted C6- C18aryl, and optionally substituted C1-C18heteroaryl; R5 is selected H, optionally substituted C1-C12alkyl, optionally substituted C2- C12alkenyl, optionally substituted optionally substituted C1-C12 haloalkyl, optionally substituted C3-C12cycloalkyl, optionally substituted C6- C18aryl, and optionally substituted C1- Ci18heteroaryl; or a pharmaceutically acceptable salt, N-oxide, or prodrug thereof.
Divergent synthesis of 4,6-diarylated pyridin-2(1H)-ones from chalcones: novel access to 2,4,6-triaryl pyridines
Khajuria, Rajni,Kannaboina, Prakash,Kapoor, Kamal K.,Gupta, Annah,Raina, Gaurav,Jassal, Amanpreet Kaur,Rana, Love Karan,Hundal, Maninder S.,Das, Parthasarathi
, p. 5944 - 5954 (2015/06/08)
A wide range of 4,6-diarylated/heterylated pyridin-2(1H)-one derivatives were synthesized in good to excellent yields from 1,3-diarylated/heterylated-2-propen-1-ones (chalcones) in one pot under metal and base-free conditions. This domino reaction suggest
A solvent-free synthesis of ethyl 3,5-diaryl-1H-pyrrole-2-carboxylates via triethylphosphite mediated reductive cyclization of ethyl 2-nitro-5-oxo-3,5- diarylpentanoates under microwave irradiation
Khajuria, Rajni,Saini, Yeshwinder,Kapoor, Kamal K.
, p. 5699 - 5702 (2013/09/24)
Ethyl 3,5-diaryl-1H-pyrrole-2-carboxylates have been synthesized in good yields from ethyl 2-nitro-5-oxo-3,5-diarylpentanoates by treatment with triethylphosphite under microwave irradiation. The integrity of the mechanism proposed has been augmented by
Enantioselective conjugate addition of nitro compounds to α,β-unsaturated ketones: An experimental and computational study
Manzano, Ruben,Andres, Jose M.,Alvarez, Rosana,Muruzabal, Maria D.,De Lera, Angel R.,Pedrosa, Rafael
supporting information; experimental part, p. 5931 - 5938 (2011/07/08)
A series of chiral thioureas derived from easily available diamines, prepared from α-amino acids, have been tested as catalysts in the enantioselective Michael additions of nitroalkanes to α,β-unsaturated ketones. The best results are obtained with the bi
Formation of γ-oxoacids and 1 H-pyrrol-2(5 H)-ones from α,β-unsaturated ketones and ethyl nitroacetate
Aginagalde, Maialen,Bello, Tamara,Masdeu, Carme,Vara, Yosu,Arrieta, Ana,Cossio, Fernando P.
supporting information; experimental part, p. 7435 - 7438 (2010/12/25)
Michael addition of ethyl nitroacetate on α,β-unsaturated ketones followed by Nef oxidation under hydrolytic conditions yields γ-oxoacids instead of the corresponding α,δ-dioxoesters. A concerted decarboxylation step is proposed on the basis of computational results. Finally, conversion of the γ-ketoacids thus prepared into 1H-pyrrol-2(5H)-ones by reaction with primary amines under Paal-Knorr conditions is also reported.
A study of the effects of subunit pre-orientation for diarylpyrrole esters; design of new aryl-heteroaryl fluorescent sensors
Killoran, John,Gallagher, John F.,Murphy, Paul V.,O'Shea, Donal F.
, p. 1258 - 1265 (2007/10/03)
The synthesis, single crystal X-ray structures, spectroscopic properties and molecular mechanics calculations of three systematically substituted 3,5-diaryl-1H-pyrrole-2-carboxylic acid ethyl esters 1a-c are described. The goal is to develop design princi
Synthetic Enzymes. Part 2. Catalytyc Asymmetric Epoxidation by means of Polyamino-acids in a Triphase System
Julia, Sebastian,Guixer, Joan,Masana, Jaume,Rocas, Jose
, p. 1317 - 1324 (2007/10/02)
The asymmetric epoxidation of several chalcones and other electron-poor olefins, in the presence of catalytic amounts of poly-(S)-amino-acids in a triphase system with optical yields of up to 96percent is described.The influence of the molecular structure of the catalysts and substrates, the solvent, and the temperature on the stereochemistry is discussed.
