244262-58-6

Basic information

• Product Name: 1,1-bis[3,3-(3'-chloro-4'-hydroxy-5'-methoxycarbonylbenzyl)-4-hydroxy-5-methoxycarbonylphenyl]-2-chloroethane
• Synonyms: 1,1-bis[3,3-(3'-chloro-4'-hydroxy-5'-methoxycarbonylbenzyl)-4-hydroxy-5-methoxycarbonylphenyl]-2-chloroethane
• CAS NO: 244262-58-6
• Molecular Weight: 761.994
• Mol File: 244262-58-6.mol

Chemical Properties

• CAS DataBase Reference: 1,1-bis[3,3-(3'-chloro-4'-hydroxy-5'-methoxycarbonylbenzyl)-4-hydroxy-5-methoxycarbonylphenyl]-2-chloroethane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-bis[3,3-(3'-chloro-4'-hydroxy-5'-methoxycarbonylbenzyl)-4-hydroxy-5-methoxycarbonylphenyl]-2-chloroethane(244262-58-6)
• EPA Substance Registry System: 1,1-bis[3,3-(3'-chloro-4'-hydroxy-5'-methoxycarbonylbenzyl)-4-hydroxy-5-methoxycarbonylphenyl]-2-chloroethane(244262-58-6)

Safety Data

• Hazardous Substances Data: 244262-58-6(Hazardous Substances Data)

Upstream product

• 97-97-2 chloroacetaldehyde dimethyl acetal 
• 244262-55-3 1,1-bis[3-chloro-4',6-dihydroxy-5,5'-dimethoxycarbonyldiphenyl]methane 
• 89-55-4 5-bromosalicyclic acid 
• 134948-41-7 5-bromo-3-formyl-2-hydroxybenzoic acid 
• 244262-46-2 3-bromo-6-hydroxy-5-hydroxymethylbenzoic acid 
• 244262-52-0 1,1-bis[3-chloro-3',5-carbonxy=2,4'-dihydroxydiphenyl]methane 
• 244262-49-5 1,1-bis[3-bromo-3'-chloro-4',6-dihydroxy-5,5'-dimethoxycarbonyl diphenyl]methane 

Downstream Products

• 244262-88-2 C₃₆H₃₀Cl₂O₁₂ 
• 244262-64-4 3,3'-di(3'-chloro-4'-methoxy-5'-methoxycarbonyl-benzyl)-4,4'-dimethoxy-5,5'-dimethoxycarbonylbenzophenone 
• 244262-61-1 1,1-bis[3,3-(3'-chloro-4'-methoxy-5'-methoxycarbonylbenzyl)-4-methoxy-5-methoxycarbonylphenyl]-2-chloroethane 

Relevant articles and documents

Synthesis and Anti-HIV Activity of Cosalane Analogues with Substituted Benzoic Acid Rings Attached to the Pharmacophore through Methylene and Amide Linkers

The cosalane pharmacophore has been extended by the attachment of two additional substituted benzoic acid rings through amide and methylene linkers. The resulting compounds display significant antiviral activity when tested in vitro for inhibition of the cytopathic effects of HIV-1RF in CEM-SS cells and HIV-1HIB in MT-4 cells. The compound containing the methylene linker also shows moderate activity versus HIV-2ROD in MT-4 cells. Because cosalane and related compounds containing extended pharmacophores inhibit the binding of gp120 to CD4, the presently described new compounds are assumed to act by a similar mechanism. A hypothetical model is proposed for the binding of the methylene-linked compound to CD4.